Patient-Reported Outcomes Following Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer

This study is open for patients with non-small cell lung cancer. This study offers such
patients the chance for a shorter and more personalized treatment course utilizing PET
imaging.

Patients will be stratified based on performance status and tumor size and randomized to one
of two treatment plans:

1. PET-based, dose-painted, accelerated chemoradiotherapy over 4 weeks (20 radiotherapy
fractions)

2. Standard chemoradiotherapy over 6 weeks (30 radiotherapy fractions)

All patients will receive standard weekly doses of chemotherapy (carboplatin and paclitaxel)
during radiotherapy. This may be followed by adjuvant systemic therapy, at the discretion of
the treating physicians.

All patients will undergo standard evaluations prior to enrollment, during treatment, and
after treatment. Additionally, patient-reported outcomes will be assessed periodically using
a PRO-CTCAE tool.

Inclusion Criteria:

Pathologically proven (either histologic or cytologic) diagnosis of NSCLC with any of the
following stages (according to the AJCC Staging Manual, 7th edition,

Appendix):

- Stage IIIA or IIIB

- Stage II NSCLC with contraindication to curative surgical resection

- Stage IV disease with solitary brain metastasis that has been treated radically (eg:
with surgical resection and/or stereotactic radiosurgery) and thoracic disease that
would be classified as stage II-III

Appropriate diagnostic/staging workup, including:

- Complete history and physical examination

- PET/CT within 42 days prior to study entry demonstrating hypermetabolic pulmonary
lesion(s) and/or thoracic lymph node(s). If PET/CT was obtained more than 42 days
prior to study entry and is not repeated, chest CT within 28 days prior to study entry
demonstrating stable disease is required.

- MRI of the brain or head CT with contrast within 42 days prior to study entry

- No prior chemotherapy or thoracic radiotherapy for lung cancer

- ECOG Performance Status 0-2

- Age > 18

- Able to read and write in one of the following languages, in which the PROCTCAE tool
is available: English, Danish, German, Italian, Japanese, Korean, Spanish

- Laboratory studies obtained within 28 days prior to study entry demonstrating adequate
bone marrow and end organ function

- Women of childbearing potential must have a negative serum or urine pregnancy test
within 72 hours prior to the start of study therapy, agree to utilize an adequate
method of contraception throughout treatment and for at least 4 weeks after study
therapy is completed,and be advised of the importance of avoiding pregnancy during
trial participation and the potential risks of an unintentional pregnancy.

All patients must sign study specific informed consent prior to study entry.

Exclusion Criteria:

- Pleural or pericardial effusion (A patient with pleural effusion may be enrolled the
effusion is sampled by thoracentesis and cytology is negative or the effusion is seen
on axial imaging but not on chest x-ray and deemed too small to tap under CT or
ultrasound guidance.)

- Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for
treatment of either a psychiatric or physical (e.g., infectious) illness

- Women who are unwilling or unable to use an acceptable method to avoid pregnancy for
the entire study period and for at least 4 weeks after cessation of study therapy

- have a positive pregnancy test at baseline

- are pregnant or breastfeeding

- Poorly controlled diabetes (defined as fasting glucose level > 200 mg/dL) despite
attempts to improve glucose control by fasting duration and adjustment of medications.
Patients with diabetes will preferably be scheduled for PET/CT imaging in the morning,
and instructions for fasting and use of medications will be provided in consultation
with the patients' primary physicians