A Study of Optical Imaging With Light From Radiotracers in Cancer Patients

Inclusion Criteria:

- Participant is 18 years of age or old

- Participant must meet one of the following:

- Patients with thyroid cancer scheduled for thyroid ablation therapy with 131I

- Patients with any tumors with (existing or suspected) nodal metastases in the
neck, supraclavicular, axillary and/or inguinal region who are scheduled to
receive a clinical FDG PET/CT scan

- Patients with metastatic prostate cancer who are schedule for Xofigo therapy with
223Ra

- Patients scheduled to receive a standard of care 66Ga-DOTA-TATE scan in the
Nuclear Medicine Clinic

Exclusion Criteria:

- Patients imaged for Cerenkov luminescence are going to be required to be in a darkened
enclosure for at least 10 minutes and sit still during image acquisition. Any
conditions that would prevent this will exclude the patients. This includes patients
who unable to sit in a dark environment, have claustrophobic, inability to sit still
for a few minutes

- Any other past medical, physiological or demographic concerns. This includes any
patients with skin blemishes that are present at the dermis over the tumor, as these
are of particular interest for use of this technique. This also includes open wounds
on the area of interest.