Collection of Blood in Studying Metabolites in Patients With Prostate Cancer
| Status: | Recruiting |
|---|---|
| Conditions: | Prostate Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/17/2018 |
| Start Date: | November 14, 2017 |
| End Date: | November 14, 2020 |
| Contact: | Brandi Scott |
| Email: | Brandi.Scott@med.usc.edu |
| Phone: | 310-272-7653 |
Metabolic Profiling of Peripheral Blood Mononuclear Cells (PBMCs) by LC-MS in Prostate Cancer Patients
This pilot research trial utilizes the collection of blood in studying metabolites in
patients with prostate cancer. Metabolites are the small molecule products of cellular
metabolism that are produced naturally in all living cells. Collecting blood in order to
study metabolites may help doctors monitor and treat prostate cancer more effectively.
patients with prostate cancer. Metabolites are the small molecule products of cellular
metabolism that are produced naturally in all living cells. Collecting blood in order to
study metabolites may help doctors monitor and treat prostate cancer more effectively.
PRIMARY OBJECTIVES:
I. Develop blood sample collection and preparation procedures for reliable, meaningful
metabolomic profiling of peripheral blood mononuclear cells (PBMCs) by liquid
chromatography/quadruple-time of flight/mass spectrometry (LC/Q-TOF/MS) that can be
implemented in a clinical setting.
II. Optimize data analysis methods and software usage to create a metabolic profile for
patients at the time of blood collection.
III. Compare metabolite profiles of isolated PBMCs versus (vs.) other blood fractions
(plasma, red blood cells [RBCs], and whole blood).
IV. Identify elements of the PBMC metabolite profile that may correlate to patient disease
state.
OUTLINE:
Patients undergo collection of blood for metabolic profiling via LC/Q-TOF/MS.
I. Develop blood sample collection and preparation procedures for reliable, meaningful
metabolomic profiling of peripheral blood mononuclear cells (PBMCs) by liquid
chromatography/quadruple-time of flight/mass spectrometry (LC/Q-TOF/MS) that can be
implemented in a clinical setting.
II. Optimize data analysis methods and software usage to create a metabolic profile for
patients at the time of blood collection.
III. Compare metabolite profiles of isolated PBMCs versus (vs.) other blood fractions
(plasma, red blood cells [RBCs], and whole blood).
IV. Identify elements of the PBMC metabolite profile that may correlate to patient disease
state.
OUTLINE:
Patients undergo collection of blood for metabolic profiling via LC/Q-TOF/MS.
Inclusion Criteria:
- All subjects will have histologically confirmed prostate cancer
- Provide written consent/authorization to participate in this study
- Have no signs or symptoms of active infection
- Exhibit a willingness to comply with the experimental procedures as outlined in this
protocol
We found this trial at
1
site
1441 Eastlake Ave
Los Angeles, California 90033
Los Angeles, California 90033
(323) 865-3000
Principal Investigator: Jonathan Katz
Phone: 323-205-5289
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
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