A Study to Evaluate the Safety and Efficacy of JNJ-64565111 in Non-diabetic Severely Obese Participants

Inclusion Criteria:

- Body mass index (BMI) greater than or equal to (>=) 35 to less than or equal to (<=)
50 kilogram per square meter (kg/m^2) at the screening visit

- Stable weight (that is, change of <= 5 percent [%] within 12 weeks before screening
based on medical history)

- Women must be either: (a) Postmenopausal, or (b) Permanently sterilized or otherwise
be incapable of pregnancy, or (c) Heterosexually active and practicing a highly
effective method of birth control, or (d) Not heterosexually active

- Woman of childbearing potential have a negative pregnancy test at screening

- Willing and able to adhere to specific the prohibitions and restrictions

Exclusion Criteria:

- History of obesity with a known secondary cause (for example, Cushing's
disease/syndrome)

- History of Type 1 diabetes mellitus, Type 2 diabetes mellitus (T2DM), diabetic
ketoacidosis (DKA), pancreas or beta-cell transplantation, or diabetes secondary to
pancreatitis or pancreatectomy

- Has a Hemoglobin A1c (HbA1c) of >= 6.5% or fasting plasma glucose (FPG) >= 126
milligrams per deciliter (mg/dL) (>= 7.0 millimoles per liter [mmol/L]) at screening

- Screening calcitonin of >= 50 picograms per milliliter (pg/mL) personal history or
family history of medullary thyroid cancer, or of multiple endocrine neoplasia
syndrome type 2 (MEN 2), regardless of time prior to screening

- History of glucagonoma