Mitochondrial Capacity in Pregnant Women
| Status: | Recruiting |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 4/17/2018 |
| Start Date: | March 19, 2018 |
| End Date: | December 31, 2019 |
| Contact: | Abby D Altazan, MS |
| Email: | abby.altazan@pbrc.edu |
| Phone: | 225-763-2801 |
The Effect of Physical Activity on in Vivo and in Vitro Mitochondrial Capacity in Pregnant Women
This Pilot & Feasibility study will test the hypothesis that pregnant women who are more
active will have better functioning mitochondria in vivo (higher ATPmax, via 31P-MRS), which
will be positively related to maternal and infant mitochondrial function in vitro (higher
oxygen consumption rates in primary myotubes and umbilical cord derived mesenchymal stem
cells, respectively). Twenty pregnant women (10 active and 10 sedentary) will be recruited in
the first trimester of pregnancy determined from self-reported physical activity and
assessment by activity monitors. Placental biospecimens will be collected during delivery for
other molecular mitochondrial analyses.
active will have better functioning mitochondria in vivo (higher ATPmax, via 31P-MRS), which
will be positively related to maternal and infant mitochondrial function in vitro (higher
oxygen consumption rates in primary myotubes and umbilical cord derived mesenchymal stem
cells, respectively). Twenty pregnant women (10 active and 10 sedentary) will be recruited in
the first trimester of pregnancy determined from self-reported physical activity and
assessment by activity monitors. Placental biospecimens will be collected during delivery for
other molecular mitochondrial analyses.
Inclusion Criteria:
- Pregnant female
- BMI between 18.5 kg/m2 and 30.0 kg/m2 prior to the current pregnancy (determined by
self report and confirmation of pregravid BMI of the index pregnancy from the prenatal
record)
- Medically cleared for participation in the study by primary care obstetrician or
midwife
- Medically cleared for participation by the Medical Investigator
- Medical record release (prenatal record, hospital delivery record) for study staff to
access information in the medical record related to the current and if applicable, the
prior pregnancy.
Exclusion Criteria:
- Risk of early delivery (eg. history of preterm birth, spontaneous abortion, evidence
of gestational hypertension (SBP >160 mmHg & DBP >110 mmHg) or pre-eclampsia in the
current pregnancy)
- History of intrauterine growth-restriction
- Persistent second- or third-trimester bleeding
- Placenta previa after 26 weeks gestation
- Incompetent cervix or cerclage
- Severe anemia
- High-order pregnancy (e.g. triplets)
- Family history of diabetes
- Heart or lung disease
- HIV or AIDS (self-reported)
- Individuals with contraindication to magnetic resonance spectroscopy such as having
magnetic metallic objects in their body
- Unwillingness for placental biospecimens to be collected at delivery
We found this trial at
1
site
6400 Perkins Rd
Baton Rouge, Louisiana 70808
Baton Rouge, Louisiana 70808
(225) 763-2500
Principal Investigator: Nicholas T Broskey, PhD
Phone: 225-763-2801
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