Thora-3DI™ for Evaluation of Severity of Chronic Obstructive Pulmonary Disease (COPD)
| Status: | Recruiting |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/17/2018 |
| Start Date: | May 1, 2017 |
| End Date: | January 1, 2019 |
| Contact: | Chris Landon, MD |
| Email: | chris.landon@ventura.org |
| Phone: | 805-652-6255 |
Tidal Breathing Patterns Measured by Thora-3DI™ Structured Light Plethysmography for Evaluation of Severity of Chronic Obstructive Pulmonary Disease (COPD)
To demonstrate differences in tidal breathing patterns measured by SLP(Structured Light
Plethysmography) between healthy subjects and COPD (chronic obstructive pulmonary disease).
The correlation between SLP parameters and standard lung function parameters measured by body
box and spirometry will also be assessed. Trends in SLP breathing patterns between the
different GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages of COPD, and
between those and healthy subjects, will be investigated to assess whether SLP can detect
differences between groups.
Plethysmography) between healthy subjects and COPD (chronic obstructive pulmonary disease).
The correlation between SLP parameters and standard lung function parameters measured by body
box and spirometry will also be assessed. Trends in SLP breathing patterns between the
different GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages of COPD, and
between those and healthy subjects, will be investigated to assess whether SLP can detect
differences between groups.
Structured light plethysmography (SLP) is a novel, non-contact method for assessing quiet
'tidal' breathing. A number of studies have reported the effects of conditions such as
chronic obstructive pulmonary disease (COPD) on tidal breathing patterns, and a previous
study has shown that SLP is able to detect differences in ten tidal breathing patterns
between healthy subjects and patients with COPD. In this present study, the investigators
will aim to confirm the previous findings and also to examine the relationship between SLP
tidal breathing parameters and traditional measurements of lung function measured by
spirometry and body box plethysmograph. The correlation between SLP parameters with lung
Function parameters measured by spirometry and body box plethysmography: forced expiratory
volume in one second (FEV1); Forced vital capacity (FVC), FEV1/FVC (forced expiratory volume
in one second/forced vital capacity); total lung capacity (TLC) and residual volume (RV).
Trends in tidal breathing patterns between varying severities of COPD (based on the (Global
initiative for lung disease (GOLD) grading system.
'tidal' breathing. A number of studies have reported the effects of conditions such as
chronic obstructive pulmonary disease (COPD) on tidal breathing patterns, and a previous
study has shown that SLP is able to detect differences in ten tidal breathing patterns
between healthy subjects and patients with COPD. In this present study, the investigators
will aim to confirm the previous findings and also to examine the relationship between SLP
tidal breathing parameters and traditional measurements of lung function measured by
spirometry and body box plethysmograph. The correlation between SLP parameters with lung
Function parameters measured by spirometry and body box plethysmography: forced expiratory
volume in one second (FEV1); Forced vital capacity (FVC), FEV1/FVC (forced expiratory volume
in one second/forced vital capacity); total lung capacity (TLC) and residual volume (RV).
Trends in tidal breathing patterns between varying severities of COPD (based on the (Global
initiative for lung disease (GOLD) grading system.
Inclusion Criteria:
- Age range 18-80 years,
- BMI range 18-40 kg/m2
- Patients diagnosed, or suspected, with COPD or normal subjects with no previous or
current diagnosis of respiratory disease
Exclusion Criteria:
- Patient unable to sit in an upright position for required period of time
- Patients with significant co morbidities (assessed by the clinician at screening
only):
- Significant unilateral lung disease e.g. pneumonectomy
- Chest wall or spinal deformity e.g. scoliosis
- Obstructive sleep apnea (OSA), Apnoea hypopnoea index > 30 (if known)
- BMI>40
- Inability to consent/comply with trial protocol
- Presence of an acute disease process that might interfere with test performance, e.g.
Nausea, vomiting, persistent coughing)
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