Utility of Lung Clearance Index Score as a Noninvasive Marker of Deployment Lung Disease
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Bronchitis, Pneumonia, Pulmonary, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/22/2018 |
| Start Date: | July 2014 |
| End Date: | January 2019 |
The purpose of this study is to learn more about new noninvasive ways of detecting lung
disease in US Military personnel and people who worked as contractors during military
operations in Iraq and Afghanistan. This study is looking at conducting a type of breathing
test called the lung clearance index (LCI) test which is being investigated as a potential
noninvasive way to detect the type of lung disease that may be seen in symptomatic deployers
retuning from Iraq and Afghanistan.
disease in US Military personnel and people who worked as contractors during military
operations in Iraq and Afghanistan. This study is looking at conducting a type of breathing
test called the lung clearance index (LCI) test which is being investigated as a potential
noninvasive way to detect the type of lung disease that may be seen in symptomatic deployers
retuning from Iraq and Afghanistan.
The healthy control group will comprise 20 volunteers who are at least 18 years of age, have
no history of pre-existing lung disease, and report no respiratory illness in the four weeks
preceding enrollment.
The symptomatic deployers who have undergone lung biopsy and meet case definition for
deployment-related lung disease. A case of deployment-related lung disease is defined as the
presence of unexplained chest symptoms in a deployer who, on a surgical lung biopsy, is found
to have bronchiolitis or granulomatous pneumonitis without other known cause.
no history of pre-existing lung disease, and report no respiratory illness in the four weeks
preceding enrollment.
The symptomatic deployers who have undergone lung biopsy and meet case definition for
deployment-related lung disease. A case of deployment-related lung disease is defined as the
presence of unexplained chest symptoms in a deployer who, on a surgical lung biopsy, is found
to have bronchiolitis or granulomatous pneumonitis without other known cause.
Inclusion Criteria:
For the deployer group:
- presence of respiratory symptoms (cough, chest tightness, wheezing, shortness of
breath or decreased exercise tolerance) following deployment
- history of deployment for Operation Iraqi Freedom, Operation Enduring Freedom or
Operation New Dawn for greater than or equal to 6 weeks as either military personnel
or a civilian contractor
- prior VATS biopsy-proven histologic abnormalities of small airways disease.
For the control group:
- no history of pre-existing lung disease
- no respiratory illness in the four weeks preceding enrollment
Exclusion Criteria:
For the deployer group:
- If on clinical evaluation they were found to have asthma, vocal cord dysfunction or
other explanations for their respiratory symptoms and did not need to undergo surgical
lung biopsy for diagnosis.
- unable to provide informed consent
- pregnant subjects
For the control group:
- pre-existing lung disease
- unable to provide informed consent
- pregnant subjects
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