EEG Studies of Sevoflurane-Induced General Anesthesia
| Status: | Completed |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 8/19/2018 |
| Start Date: | May 1, 2018 |
| End Date: | August 1, 2018 |
Electroencephalogram Studies of Induction and Recovery From Sevoflurane-Induced General Anesthesia
The investigators are performing this research study to find out how and where the anesthetic
drugs sevoflurane and ketamine act in the brain. Sevoflurane and ketamine are anesthetics (a
drug or agent used to decrease or eliminate the feeling of pain by causing unconsciousness).
The investigators will study the brain using a machine that records the brain's electrical
activity, called an electroencephalogram (EEG).
drugs sevoflurane and ketamine act in the brain. Sevoflurane and ketamine are anesthetics (a
drug or agent used to decrease or eliminate the feeling of pain by causing unconsciousness).
The investigators will study the brain using a machine that records the brain's electrical
activity, called an electroencephalogram (EEG).
During this research study, participants will receive sevoflurane, and sevoflurane and
ketamine together, at a high enough dose to induce general anesthesia (make study
participants "fall asleep"). During one visit participants will receive only sevoflurane;
during another visit participants will be given both sevoflurane and ketamine together. The
investigators will record EEG the entire time. The investigators will also ask some questions
related to pain and cognitive function.
ketamine together, at a high enough dose to induce general anesthesia (make study
participants "fall asleep"). During one visit participants will receive only sevoflurane;
during another visit participants will be given both sevoflurane and ketamine together. The
investigators will record EEG the entire time. The investigators will also ask some questions
related to pain and cognitive function.
Inclusion Criteria:
- Between the ages of 18 and 50
- Normal body weight and habitus, BMI ≤ 30
- Non-smoker
- American Society of Anesthesiologists (ASA) physical status classification P1
Exclusion Criteria:
- Chronic health conditions
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