Media, Morphokinetics, and Mosaicism
| Status: | Recruiting |
|---|---|
| Conditions: | Women's Studies, Infertility |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - 42 |
| Updated: | 4/22/2018 |
| Start Date: | February 14, 2018 |
| End Date: | January 1, 2021 |
| Contact: | Molly Quinn, MD |
| Email: | molly.quinn@ucsf.edu |
| Phone: | 4153537475 |
Aneuploidy Rates and Morphokinetic Parameters in Sibling Embryos Cultured in Distinct Culture Media
Embryonic aneuploidy is the underlying etiology for the majority of failed implantation and
miscarriage. Preimplantation genetic screening (PGS) with transfer of a euploid embryo has
been advocated as a strategy for increasing live birth rates with a single embryo transfer.
Culturing embryos to the blastocyst stage for trophectoderm biopsy is a requirement for PGS.
Several commercially-available single-step embryonic culture media with varying composition
have been established for use in the IVF laboratory. Early reports have suggested differences
in clinical outcomes, such as aneuploidy and miscarriage rates, with distinct culture media
currently in standard use.1,2 However, there have been no clinical trials demonstrating the
superiority of any one commercially-available culture media formulation. As a result, clinics
use media with varying composition based upon familiarity and cost.
miscarriage. Preimplantation genetic screening (PGS) with transfer of a euploid embryo has
been advocated as a strategy for increasing live birth rates with a single embryo transfer.
Culturing embryos to the blastocyst stage for trophectoderm biopsy is a requirement for PGS.
Several commercially-available single-step embryonic culture media with varying composition
have been established for use in the IVF laboratory. Early reports have suggested differences
in clinical outcomes, such as aneuploidy and miscarriage rates, with distinct culture media
currently in standard use.1,2 However, there have been no clinical trials demonstrating the
superiority of any one commercially-available culture media formulation. As a result, clinics
use media with varying composition based upon familiarity and cost.
Inclusion Criteria:
All subjects planning blastocyst culture for preimplantation genetic screening (PGS) will
be offered enrollment.
AFC >8 Male and female partner > 18 years of age
Exclusion Criteria:
Female partner age >42 years of age Cleavage stage biopsy
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