Study Investigating the Effect of Lu AF35700 on Cardiac Repolarization in Men and Women With Schizophrenia and Schizoaffective Disorder

Inclusion Criteria:

- The patient is able by her/himself to provide informed consent to participate in the
study

- The patient has a primary diagnosis of schizophrenia or schizoaffective disorder
(DSM-5™ criteria)

- The patient has BMI ≤35 kg/m2

- The patient has a Clinical Global Impression - Severity of Illness (CGI-S) score ≤4
(moderately ill)

- PANSS total score ≤ 80 and a score ≤4 (moderate) on the PANSS items, P7 (hostility)
and G8 (uncooperativeness)

- The patient is willing to be hospitalized for up to 8 weeks

- The patient is generally healthy based on medical history, physical examination, vital
signs, ECG, and laboratory tests.

- The patient agrees to protocol-defined use of effective contraception

Exclusion Criteria:´

- The patient experienced acute exacerbation of psychosis requiring hospitalization
within the last 3 months or required change in medication due to exacerbation of
psychosis within the last 8 weeks

- The patient has met moderate or severe co-morbid Substance Abuse Disorder DSM-5™
criteria in the last 3 months

- The patient is at significant risk of harming her/himself or others in the opinion of
the investigator or according to Columbia Suicide Severity Rating Scale (C-SSRS)

- The patient has tested positive for human immunodeficiency virus (HIV), hepatitis B
surface antigen (HBsAg), or hepatitis C virus antibody (anti-HCV)

Other protocol defined inclusion and exclusion criteria may apply