Targeted PET/CT and PET/MRI Imaging of Vascular Inflammation
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Cardiology, Cardiology, Cardiology, Cardiology, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/26/2018 |
| Start Date: | June 2018 |
| End Date: | December 2019 |
| Contact: | Michael V. McConnell, MD, MSEE |
| Email: | mcconnell@stanford.edu |
| Phone: | (650) 723-6459 |
Stroke and abdominal aortic aneurysms (AAAs) are common and highly lethal vascular diseases.
Angiogenesis and infiltration of inflammatory cells such as macrophages may cause stroke and
AAAs.
The purpose of this study is to test PET/CT and PET/MRI imaging to specifically detect those
diseases using a new developed agent (18F-FPPRGD2) that can target angiogenesis and
macrophages.
Angiogenesis and infiltration of inflammatory cells such as macrophages may cause stroke and
AAAs.
The purpose of this study is to test PET/CT and PET/MRI imaging to specifically detect those
diseases using a new developed agent (18F-FPPRGD2) that can target angiogenesis and
macrophages.
20 subjects with either carotid bifurcation stenosis of >50% by ultrasound on at least one
side (10 patients) or advanced AAAs (10 patients) and surgical intervention planned will be
identified from physicians from the Division of Vascular Surgery at Stanford.
Either a PET/CT or a PET/MRI will be performed for each subject:
- PET/CT scans will be performed in 3D mode using GE Discovery 600 or GE Discovery 690
scanners (GE Healthcare).
- PET/MRI scans will be performed using the novel PET/MRI system at Stanford, including a
sensitive PET time-of-flight (TOF) scanner with an advanced 3T MRI scanner.
The study patients will receive an intravenous administration of 10mCi of the prescribed
radiotracer (18F-FPPRGD2). PET/CT or PET/MRI images will be obtained starting 45-60 minutes
after radiotracer administration. For PET/CT, each image acquisition will begin with a
non-contrast CT scan obtained from the vertex through the mid-thighs of the subjects. For
PET/MRI, non-contrast images of the carotid or aorta will be performed. PET imaging will
follow. Patient's vital signs will be monitored during the procedure and a physician will be
available if there is need for immediate medical attention. The PET images will be
reconstructed with a standard iterative algorithm using GE software release 5.0.
After the planned surgery, we will also assess the histopathological correlation between the
disease lesions and PET/CT or PET/MRI imaging characteristics.
side (10 patients) or advanced AAAs (10 patients) and surgical intervention planned will be
identified from physicians from the Division of Vascular Surgery at Stanford.
Either a PET/CT or a PET/MRI will be performed for each subject:
- PET/CT scans will be performed in 3D mode using GE Discovery 600 or GE Discovery 690
scanners (GE Healthcare).
- PET/MRI scans will be performed using the novel PET/MRI system at Stanford, including a
sensitive PET time-of-flight (TOF) scanner with an advanced 3T MRI scanner.
The study patients will receive an intravenous administration of 10mCi of the prescribed
radiotracer (18F-FPPRGD2). PET/CT or PET/MRI images will be obtained starting 45-60 minutes
after radiotracer administration. For PET/CT, each image acquisition will begin with a
non-contrast CT scan obtained from the vertex through the mid-thighs of the subjects. For
PET/MRI, non-contrast images of the carotid or aorta will be performed. PET imaging will
follow. Patient's vital signs will be monitored during the procedure and a physician will be
available if there is need for immediate medical attention. The PET images will be
reconstructed with a standard iterative algorithm using GE software release 5.0.
After the planned surgery, we will also assess the histopathological correlation between the
disease lesions and PET/CT or PET/MRI imaging characteristics.
Inclusion Criteria:
- Greater than 18 year-old at the time of radiotracer administration
- Provides written informed consent
- Patients diagnosed with either carotid artery stenosis or abdominal aortic aneurysms
(AAAs) as identified in Vascular Surgery, in whom a surgical procedure is scheduled
- Able to remain still for duration of an imaging procedure (about one hour).
Exclusion Criteria:
- Less than 18 year-old at the time of radiotracer administration
- Unable to provide written informed consent
- Pregnant women
- Prior carotid or abdominal surgery
- History of radiation therapy to the neck and abdomen
- MRI contraindications (including ferromagnetic objects or devices).
We found this trial at
1
site
450 Serra Mall
Stanford, California 94305
Stanford, California 94305
(650) 723-2300
Principal Investigator: Guido Davidzon, MD
Phone: 650-736-4183
Stanford University Stanford University, located between San Francisco and San Jose in the heart of...
Click here to add this to my saved trials
