Immunologic Effects of Echinacea
| Status: | Completed |
|---|---|
| Conditions: | Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 21 - 65 |
| Updated: | 5/3/2018 |
| Start Date: | March 2009 |
| End Date: | August 2009 |
Study of the Immunologic Effects of Echinacea Purpurea in Adults
The goal of this study is to determine if Echinacea purpurea stimulates the immune system.
For the study, 20 healthy adults will be randomized to receive Echinacea purpurea or placebo
for 10 days. Blood will be drawn to assess immune markers just before beginning the study
medication, during the 10 day course of medication and after completing the course of
medication. It is postulated that adults receiving the Echinacea will have evidence of immune
stimulation and those receiving placebo will not.
For the study, 20 healthy adults will be randomized to receive Echinacea purpurea or placebo
for 10 days. Blood will be drawn to assess immune markers just before beginning the study
medication, during the 10 day course of medication and after completing the course of
medication. It is postulated that adults receiving the Echinacea will have evidence of immune
stimulation and those receiving placebo will not.
Inclusion Criteria:
- Healthy adults 21-65 years old
- If female of child-bearing potential, willing to use contraception to prevent
pregnancy
- Speaks and reads English
- No use of any medication (other than multivitamins, essential fatty acids or
probiotics)
- Willing to abstain from ingesting edible mushrooms throughout study
- Willing to eat less than 2 garlic cloves per day throughout study
Exclusion Criteria:
- Positive pregnancy test or currently breastfeeding
- History of autoimmune disease
- History of allergic rhinitis
- History of physician diagnosed eczema
- Known allergic reaction to Echinacea or related species, specifically ragweed
(Ambrosia), chamomile (Matricaria), goldenrod (Solidago) and sunflower (Helianthus)
- Use of any medication within 30 days prior to first dose of study medication that is a
known inhibitor or inducer of CYP34A
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