Using MC1R Genotype to Impact Melanoma Risk Behavior

Inclusion Criteria:

CRITERIA FOR: NON-HISPANIC WHITE POPULATION - NOW RECRUITING

- Investigators will recruit participants from the Family Medicine and General Internal
Medicine clinics of the Morsani Center at the University of South Florida.

- White, non-Hispanic patients who self-report a low phenotypic risk profile for
development of melanoma and are able to read and speak English fluently.

- 18 years of age or older

- Capable of giving informed consent

- Potential participants will be screened for eligibility based on responses to
questions about skin phenotypes, early detection behaviors and past history of
melanoma.

- After signing informed consent, a biologic sample (saliva) will be collected for the
purpose of DNA extraction determination of MC1R genotypes. All participants who carry
high risk MC1R genotypes and a proportion of those who carry low risk or no MC1R
variants will be randomized to the control or intervention arm.

CRITERIA FOR: HISPANIC POPULATION - WILL BEGIN RECRUITING SOON

- Investigators will recruit participants living in Tampa Bay and Puerto Rico as part of
the U54 Ponce Health Sciences University-Moffitt Cancer Center (PHSU-MCC) Partnership.
In Tampa Bay, participants will be recruited from the Family Medicine and General
Internal Medicine clinics of the Morsani Center at the University of South Florida,
and from the Suncoast Community Health Centers.

- Patients who self-report as Hispanics and are able to read and speak either Spanish or
English fluently.

- 18 years of age or older

- Capable of giving informed consent

- Potential participants will be screened for eligibility based on responses to early
detection behaviors and past history of melanoma.

- After signing informed consent, a biologic sample (saliva) will be collected for the
purpose of DNA extraction determination of MC1R genotypes. All participants who carry
high risk MC1R genotypes and a proportion of those who carry low risk or no MC1R
variants will be randomized to the control or intervention arm.

Exclusion Criteria:

CRITERIA FOR: NON-HISPANIC WHITE POPULATION - NOW RECRUITING

- Have had a skin examination within the past year.

- Do not meet race/ethnicity criteria for their group

- White, non-Hispanic group - participants reporting sun-sensitive phenotypes

- A personal history of melanoma

CRITERIA FOR: HISPANIC POPULATION - WILL BEGIN RECRUITING SOON

- Have had a skin examination within the past year.

- Do not meet ethnicity criteria for their group

- White, non-Hispanic group - participants reporting sun-sensitive phenotypes

- Participants with a personal history of melanoma and/or more personal history of more
than on squamous cell cancer (SCC) and/or Basal Cell Cancer (BCC)