Randomized Evaluation of Ten Allergy Skin Prick Test Devices
| Status: | Completed |
|---|---|
| Conditions: | Allergy, Asthma, Asthma, Food Studies, Neurology |
| Therapuetic Areas: | Neurology, Otolaryngology, Pharmacology / Toxicology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 8/18/2018 |
| Start Date: | January 2014 |
| End Date: | September 2015 |
The goal of this study is to compare ten current and readily available FDA approved allergy
skin prick devices to determine the most sensitive and specific product and methods used for
the diagnosis of allergic disease. The primary outcome will be to determine the analytical
sensitivity and specificity of all ten skin prick devices by measuring wheal and flare
response to histamine and control diluent in 1mm increments. Secondary outcomes include
comparison of skin prick technique, optimum histamine concentration, patient comfort,
reproducibility, and the comparability of high-resolution digital images.
skin prick devices to determine the most sensitive and specific product and methods used for
the diagnosis of allergic disease. The primary outcome will be to determine the analytical
sensitivity and specificity of all ten skin prick devices by measuring wheal and flare
response to histamine and control diluent in 1mm increments. Secondary outcomes include
comparison of skin prick technique, optimum histamine concentration, patient comfort,
reproducibility, and the comparability of high-resolution digital images.
Inclusion Criteria:
- Adults aged 18-65 with or without allergic disease
Exclusion Criteria:
- severe concurrent illness
- uncontrolled asthma
- extensive eczema
- urticaria
- dermatographism
- pregnancy
- those taking antihistamines within the previous 10 days
- topical steroids
- immunomodulatory drugs
- long term use of oral steroids
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