Measurements of Resting Energy Expenditure in Patients With or at Risk of Developing Graft Versus Host Disease

Chronic Graft versus Host Disease (GVHD) is an important cause of morbidity and mortality in
patients undergoing allogeneic bone marrow and hematopoietic progenitor cell
transplantation. In adults, it has been shown that patients with acute or chronic GVHD have
an increase in their resting energy expenditure (REE), likely as a result of chronic
systemic inflammation. These studies have not yet been performed in children. This study's
objective is to determine the REE of pediatric patients with acute and chronic GVHD after
hematopoietic stem cell transplantation (HSCT).

Inclusion Criteria:

- Subjects must be 7-30 years of age

- Signed informed consent

- One of the following three criteria must be met:

- Presence of grade II or greater acute GVHD as defined by Keystone criteria

- Presence of clinically extensive chronic GVHD as defined by the revised Seattle
criteria

- Any subject identified prior to allogeneic transplant, or following allogeneic
transplant, who is at risk for acute or chronic GVHD

Exclusion Criteria:

- Inability to meet the requirements of the study procedures

- Any subject who is receiving supplemental oxygen

- Withdrawal of consent