Changes in Biomarkers Associated With Use of Electronic Cigarettes

Primary Aim: To determine changes in biomarkers associated with the use of electronic
cigarettes among African American menthol and nonmenthol smokers.

Primary Hypothesis: At 8 weeks and 24 weeks post-enrollment, there will be a significant
association between use of electronic cigarettes and biomarkers of smoking exposure such that
changes in biomarkers from baseline to follow-up will be higher among participants randomized
to the active e-cigarette condition.

Inclusion Criteria:

1. self-identify as African American or Black;

2. age 18 years or older;

3. smoke at least five cigarettes daily for the past year;

4. not interested in quitting smoking in the next 6 months;

5. Willing to use e-cigarettes;

6. Good physical health (no unstable medical or mental health condition);

7. no contraindications for e-cigarette use.

Exclusion Criteria:

1. Recent unstable or untreated psychiatric diagnosis including substance abuse, as
determined by the DSM-IV criteria;

2. use in the past 30 days of tobacco or nicotine products including e-cigarettes, other
than regular cigarettes;

3. participation in a smoking cessation program in the past 30 days;

4. pregnant or nursing.