Prognostic Value of Transforming Growth Factor-Beta 1 in Normal Pressure Hydrocephalus
| Status: | Completed |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | January 2008 |
| End Date: | July 2011 |
| Contact: | Noel Tulipan, M.D. |
| Email: | noel.tulipan@Vanderbilt.Edu |
| Phone: | 615-322-6875 |
Correlation of cerebrospinal fluid levels of transforming growth factor beta-1 with
functional improvements after insertion of ventriculoperitoneal shunt for normal pressure
hydrocephalus
functional improvements after insertion of ventriculoperitoneal shunt for normal pressure
hydrocephalus
The goal of this research is to investigate a potential CSF biomarker of NPH as a new tool
for both the diagnosis of NPH and prognosis of VPS placement. Transforming growth factor-b1
(TGF-b1) is a signaling molecule involved in three fundamental activities; suppression of
cell proliferation, immunosuppression, and deposition of extracellular matrix through
promotion of synthesis and inhibition of degradation.8 Previously, TGF-b1 had been
implicated in the development of communicating hydrocephalus secondary to pre-term infant
intraventricular hemorrhage9 and adult aneurysmal sub-arachnoid hemorrhage.10, 11 Recently,
an investigation demonstrated elevated levels of TGF-b1 in patients with shunt-responsive
NPH compared to non-NPH patients.12
The specific aims of this research proposal are to:
1. Correlate CSF levels of TGF-b1 with the clinical response of patients diagnosed with
NPH to VPS placement.
2. Correlate CSF levels of TGF-b1 with optimal VPS pressure settings.
for both the diagnosis of NPH and prognosis of VPS placement. Transforming growth factor-b1
(TGF-b1) is a signaling molecule involved in three fundamental activities; suppression of
cell proliferation, immunosuppression, and deposition of extracellular matrix through
promotion of synthesis and inhibition of degradation.8 Previously, TGF-b1 had been
implicated in the development of communicating hydrocephalus secondary to pre-term infant
intraventricular hemorrhage9 and adult aneurysmal sub-arachnoid hemorrhage.10, 11 Recently,
an investigation demonstrated elevated levels of TGF-b1 in patients with shunt-responsive
NPH compared to non-NPH patients.12
The specific aims of this research proposal are to:
1. Correlate CSF levels of TGF-b1 with the clinical response of patients diagnosed with
NPH to VPS placement.
2. Correlate CSF levels of TGF-b1 with optimal VPS pressure settings.
Inclusion Criteria:
- Diagnosis of Normal Pressure Hydrocephalus
Exclusion Criteria:
- Patients not diagnosed with Normal Pressure Hydrocephalus
We found this trial at
1
site
1211 Medical Center Dr
Nashville, Tennessee 37232
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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