Five Sessions Intervention to Facilitate Adaptation to Breast Cancer
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 21 - 75 |
| Updated: | 5/5/2018 |
| Start Date: | December 2006 |
| End Date: | June 2019 |
To test the effects of 2 different 5-wk stress management interventions (cognitive behavioral
training or relaxation training) vs. a time-matched 5-wk health education condition on
psychosocial adaptation and physiological adaptation in women being treated for breast
cancer. Participants assigned to either of the stress management conditions will show
improved psychosocial adaptation and physiological adaptation compared to those assigned to
the health education condition.
training or relaxation training) vs. a time-matched 5-wk health education condition on
psychosocial adaptation and physiological adaptation in women being treated for breast
cancer. Participants assigned to either of the stress management conditions will show
improved psychosocial adaptation and physiological adaptation compared to those assigned to
the health education condition.
The study tests the effects of two 5-wk group-based stress management interventions
(Cognitive Behavioral Training [CBT] (stress awareness, cognitive restructuring, coping
skills training, interpersonal skills training), Relaxation Training [RT] (muscle relaxation,
deep breathing, guided imagery, meditation) vs. a time-matched 5-wk group-based Health
Education Training control condition (information about breast cancer diagnosis and
treatment, side-effect management, recurrence, physical activity and nutrition, and life
after breast cancer) in women who have recently had surgery for breast cancer but have not
yet started adjuvant therapy. The study evaluates the effects of CBT and RT on psychological
adaptation (includes measures of negative adaptation [negative affect and social disruption]
and positive adaptation [positive affect and benefit finding]) at 6-month and 12-month
follow-up. The study also evaluates the effects of CBT and RT on physiological adaptation
(includes levels of PM serum cortisol and T-helper-type 1 (Th1) cytokine [interleukin-2,
IL-2, and interferon-gamma, IFN-g, production after anti-CD3 stimulation of peripheral blood
mononuclear cells (PBMCs).
(Cognitive Behavioral Training [CBT] (stress awareness, cognitive restructuring, coping
skills training, interpersonal skills training), Relaxation Training [RT] (muscle relaxation,
deep breathing, guided imagery, meditation) vs. a time-matched 5-wk group-based Health
Education Training control condition (information about breast cancer diagnosis and
treatment, side-effect management, recurrence, physical activity and nutrition, and life
after breast cancer) in women who have recently had surgery for breast cancer but have not
yet started adjuvant therapy. The study evaluates the effects of CBT and RT on psychological
adaptation (includes measures of negative adaptation [negative affect and social disruption]
and positive adaptation [positive affect and benefit finding]) at 6-month and 12-month
follow-up. The study also evaluates the effects of CBT and RT on physiological adaptation
(includes levels of PM serum cortisol and T-helper-type 1 (Th1) cytokine [interleukin-2,
IL-2, and interferon-gamma, IFN-g, production after anti-CD3 stimulation of peripheral blood
mononuclear cells (PBMCs).
Inclusion Criteria:
- women diagnosed with breast cancer at stage III or below who had recently undergone
lumpectomy or mastectomy
Exclusion Criteria:
- prior cancer, prior psychiatric treatment for a serious disorder (e.g., psychosis,
suicidality), lack of fluency in English and had begun adjuvant therapy at time of
first assessment
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