Pushing Spatiotemporal Limits for 4D Flow MRI and Dynamic MRA in the Brain at Ultra-High Field
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 5/5/2018 |
| Start Date: | November 2015 |
| End Date: | June 2019 |
| Contact: | Sean Moen |
| Email: | moen0094@umn.edu |
| Phone: | 612-624-6666 |
This study aims at investigating the blood hemodynamics with high spatiotemporal resolution
in patients with brain aneurysms and AVMs as well as in healthy controls. Parameters such as
peak blood velocity, wall shear stress and other derived parameters will be obtained from 4D
flow MRI data acquired at ultra-high field strength (7 Tesla).
in patients with brain aneurysms and AVMs as well as in healthy controls. Parameters such as
peak blood velocity, wall shear stress and other derived parameters will be obtained from 4D
flow MRI data acquired at ultra-high field strength (7 Tesla).
The hemodynamic factors responsible for hemorrhagic stroke, resulting in wide variations in
the clinical management of underlying vascular lesions, especially when they are found in
asymptomatic individuals or individuals with symptoms not related to the disease. Therefore,
there is an urgent need for the development of reliable biomarkers based on hemodynamic
parameters, which can then enable improvements in risk assessment in patients presenting with
these lesions. This need can be met by non-invasive Magnetic Resonance Imaging (MRI)
techniques that provide information on high resolution vascular anatomy, visualization of
cerebral hemodynamics and quantitative information about blood velocity. However, such
techniques as presently employed at 1.5 or 3 Tesla are limited by spatial resolution and
prolonged data acquisition times.
The primary goal of this proposal is to overcome these current limitations by exploiting
Ultra-High Fields (UHF, i.e. ≥ 7 Tesla (7T)) to attain significantly higher spatial
resolution, faster acquisitions and increased lesion conspicuity utilizing
- Qualitative exploration of intracranial blood hemodynamics,
- Quantitative imaging of the spatiotemporally resolved blood velocity vector,
- Derivation of hemodynamic parameters.
the clinical management of underlying vascular lesions, especially when they are found in
asymptomatic individuals or individuals with symptoms not related to the disease. Therefore,
there is an urgent need for the development of reliable biomarkers based on hemodynamic
parameters, which can then enable improvements in risk assessment in patients presenting with
these lesions. This need can be met by non-invasive Magnetic Resonance Imaging (MRI)
techniques that provide information on high resolution vascular anatomy, visualization of
cerebral hemodynamics and quantitative information about blood velocity. However, such
techniques as presently employed at 1.5 or 3 Tesla are limited by spatial resolution and
prolonged data acquisition times.
The primary goal of this proposal is to overcome these current limitations by exploiting
Ultra-High Fields (UHF, i.e. ≥ 7 Tesla (7T)) to attain significantly higher spatial
resolution, faster acquisitions and increased lesion conspicuity utilizing
- Qualitative exploration of intracranial blood hemodynamics,
- Quantitative imaging of the spatiotemporally resolved blood velocity vector,
- Derivation of hemodynamic parameters.
Inclusion Criteria:
- Subjects / Patients between 18 and 75
Exclusion Criteria:
- Any kind of ferromagnetic implants.
- MR-unsafe non-ferromagnetic implants.
- Cardiac pacemakers.
- A history of shrapnel or shot gun injury.
- A body mass index > 40.
- Severe claustrophobia.
- Tattoos in the head/neck area or permanent makeup.
We found this trial at
1
site
Minneapolis, Minnesota 55455
Principal Investigator: Bharathi Jagadeesan, MD
Phone: 612-624-6666
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