Skeletal Muscle Atrophy and Dysfunction in Human Cancer
| Status: | Recruiting |
|---|---|
| Conditions: | Lung Cancer, Neurology |
| Therapuetic Areas: | Neurology, Oncology |
| Healthy: | No |
| Age Range: | 50 - 75 |
| Updated: | 5/5/2018 |
| Start Date: | July 2016 |
| End Date: | June 2021 |
| Contact: | Alexandra Albertson |
| Email: | alexandra.albertson@med.uvm.edu |
| Phone: | 802-656-2178 |
Cancer and its treatment can have profound effects on skeletal muscle, the most
well-recognized being atrophy, weakness and diminished oxidative capacity. These adaptations
negatively impact quality of life, treatment decisions and survival. Despite these
consequences, the factors promoting these adaptations remain poorly defined and understudied
in human patients. To address this gap in knowledge, our goal in this study is to examine the
role of muscle disuse as a regulator of muscle size and function in human cancer patients
well-recognized being atrophy, weakness and diminished oxidative capacity. These adaptations
negatively impact quality of life, treatment decisions and survival. Despite these
consequences, the factors promoting these adaptations remain poorly defined and understudied
in human patients. To address this gap in knowledge, our goal in this study is to examine the
role of muscle disuse as a regulator of muscle size and function in human cancer patients
Inclusion Criteria:
- 50-75 yrs of age
- histologically-documented, stage III or IV non-small cell lung carcinoma (NSCLC)
- estimated life expectancy >6 mos
- Karnofsky's performance score of ≥70
Exclusion Criteria:
- history, signs or symptoms of inflammatory or autoimmune disease
- uncontrolled hypertension
- heart or renal failure
- exercise limitations from peripheral vascular disease or stroke
- neuromuscular disease
- knee/hip replacement
- additional, actively-treated malignancy or history of malignancy, except non-melanoma
skin cancer
- taking medication that can have anti-coagulant effects that cannot be stopped prior to
the muscle biopsy
We found this trial at
1
site
1 South Prospect Street
Burlington, Vermont 05401
Burlington, Vermont 05401
802-656-8990
Phone: 802-656-2178
Click here to add this to my saved trials
