4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2



Status:Recruiting
Conditions:Neurology, Neurology, Neurology, Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:40 - 80
Updated:9/19/2018
Start Date:January 2016
End Date:December 2021
Contact:Eliya Ben-Asher, BS
Email:Eliya.Ben-Asher@ucsf.edu
Phone:(415) 476-2941

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Trial Summary
Trial Overview
Inclusion Criteria

The Four-Repeat Tauopathy Neuroimaging Initiative

The goal of this study is to identify the most reliable methods of analysis for tracking CBD,
PSP, and o/vPSP over time. The results from this study may be used in the future to calculate
statistical power for clinical drug trials. The study will also provide information about the
relative value of novel imaging techniques for diagnosis, as well as the value of imaging
techniques versus testing of blood, urine, and cerebrospinal fluid (CSF) 'biomarkers'.


Inclusion Criteria:

- No known history of neurological disease, or meet criteria for one of the following:
Corticobasal Syndrome or Degeneration (CBS or CBD); Progressive Supranuclear Palsy
(PSP); or Oligo- or Variant- Progressive Supranuclear Palsy (o/vPSP)

- Needs a reliable study partner who has frequent contact with the participant, who is
available to provide information about the participant, and who can accompany the
participant to research visits as needed

- Must be willing and able to undergo testing procedures, which include longitudinal
follow-up visits

- Must be able to walk five steps with minimal assistance

Exclusion Criteria:

- Significant neurological disease other than CBD, PSP, or a variant PSP syndrome.

- Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, or
metal fragments or metal objects in the eyes, skin, or body

- In the site investigator's opinion, inability to complete sufficient key study
procedures, or some other equivalent assessment of impairment
We found this trial at
6
sites
University of California - San Diego (UCSD)
San Diego, California 92103
Principal Investigator: Irene Litvan, MD
Phone: 858-822-5751
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Harvard University Massachusetts General Hospital
Charlestown, Massachusetts 02129
Principal Investigator: Bradford C Dickerson, MD
Phone: 617-726-6205
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Charlestown, MA
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Univ of Pennsylvania
3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Principal Investigator: Murray Grossman, MD
Phone: 215-662-3596
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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Mayo Clinic Rochester
200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Principal Investigator: Bradley F Boeve, MD
Phone: 507-538-9487
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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University of California at San Francisco (UCSF)
500 Parnassus Ave
San Francisco, California 94143
(415) 476-9000
Phone: 415-476-2941
University of California at San Francisco (UCSF) The leading university exclusively focused on health, UC...
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University of Toronto
Toronto, Ontario
Principal Investigator: Maria Carmela Tartaglia, MD, FRCPC
Phone: (416) 507-6880
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Toronto,
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