Safety and Efficacy of Fenofibrate as a Treatment for Huntington's Disease
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/8/2019 |
| Start Date: | April 27, 2017 |
| End Date: | December 31, 2019 |
A Phase IIa, Randomized, Double-blind, Placebo-controlled Study of the Safety and Efficacy of Fenofibrate as a Treatment for Huntington's Disease
The purpose of this research study is to study the safety and efficacy of fenofibrate, an
FDA-approved drug for high cholesterol and/or elevated triglyerides (fats), as a treatment
for Huntington's disease (HD). Subjects who meet the entry criteria will be randomized (3:1)
to either 145mg of fenofibrate or placebo.
FDA-approved drug for high cholesterol and/or elevated triglyerides (fats), as a treatment
for Huntington's disease (HD). Subjects who meet the entry criteria will be randomized (3:1)
to either 145mg of fenofibrate or placebo.
Inclusion Criteria:
- An adult of either sex, ages 25-85 inclusive,
- Have proficiency with written and spoken English and corrected vision or hearing to
complete the cognitive testing,
- Are able to give informed consent,
- Have good overall health status with no known problems anticipated over the course of
the trial,
- Have a diagnosis of HD supported by positive gene test within the past 6 months.
Exclusion Criteria:
- Other major neurological disease [e.g., multiple sclerosis, parkinson's disease,
cortical stroke, etc]
- Clinically significant hepatic or renal disease,
- Current or recent (< 1 month) use of dopamine blocking agents such as tetrabenazine,
anticonvulsants, neuroleptics, HAART, antiemetics, and antipsychotics for any reason,
- Current use of Warfarin (Coumadin). Enrollment in another investigational drug study
within the prior three months.
We found this trial at
1
site
Irvine, California 92697
949-824-5011
Principal Investigator: Neal Hermanowicz, MD
Phone: 949-824-8116
University of California, Irvine Since 1965, the University of California, Irvine has combined the strengths...
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