Utility of Trimethoprim-sulfamethoxazole Use in Skin Abscess Management
| Status: | Completed |
|---|---|
| Conditions: | Skin and Soft Tissue Infections, Infectious Disease |
| Therapuetic Areas: | Dermatology / Plastic Surgery, Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | Any - 18 |
| Updated: | 5/6/2018 |
| Start Date: | July 2006 |
| End Date: | May 2008 |
A Double Blinded Randomized Controlled Trial for the Management of Pediatric Community Acquired Skin Abscesses - To Treat or Not to Treat With Antibiotics
The purpose of this study is to determine if antibiotics are required in the management of
skin abscess following incision and drainage.
skin abscess following incision and drainage.
This is a double-blind, randomized controlled trial at an urban pediatric emergency
department. Sample size (162) was based on a threshold equivalence of 7% (α = 0.05, power =
80%). Inclusion criteria were: non-toxic, immunocompetent, 3 months to 18 years old,
English-speaking patients with clinical or ultrasound identified skin abscesses who were not
on antibiotics. Patients were block randomized to receive placebo or
trimethoprim/sulfamethoxazole following incision and drainage. Follow-up was a call at 2-3
days & a repeat visit or call at 10-14 days. Treatment failure was defined as: persistent
erythema, tenderness, and/or draining lesions. New lesion was defined as: primary resolution
with development of new lesion (furuncle, carbuncle or abscess) at a different location.
Compliance was evaluated by the return of the study medication or by patient report.
department. Sample size (162) was based on a threshold equivalence of 7% (α = 0.05, power =
80%). Inclusion criteria were: non-toxic, immunocompetent, 3 months to 18 years old,
English-speaking patients with clinical or ultrasound identified skin abscesses who were not
on antibiotics. Patients were block randomized to receive placebo or
trimethoprim/sulfamethoxazole following incision and drainage. Follow-up was a call at 2-3
days & a repeat visit or call at 10-14 days. Treatment failure was defined as: persistent
erythema, tenderness, and/or draining lesions. New lesion was defined as: primary resolution
with development of new lesion (furuncle, carbuncle or abscess) at a different location.
Compliance was evaluated by the return of the study medication or by patient report.
Inclusion Criteria:
- non-toxic patients
- immunocompetent patients
- 3 months to 18 years old
- English-speaking patients
- skin abscesses
- not on antibiotics
Exclusion Criteria:
- toxic patients
- immunocompromising co-morbidities
- less than 3 months old or older than 18 years of age
- non-english speaking
- on antibiotics
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