Assisted Fluid Management IDE Study

The primary objective of this study is to evaluate the performance of the Acumen™ Assisted
Fluid Management (AFM) Feature in its ability to predict a subject's fluid responsiveness.

Subjects enrolled in the validation study will have their fluid management decisions guided
by the AFM Feature.

Inclusion Criteria:

- Be ≥ 18 years of age

- Abdominal, pelvic, major peripheral vascular surgery expected to last >2 hours post
anesthesia induction

- Participate or have authorized representative participate in the Informed Consent
process and sign/date the IRB approved informed consent form.

Exclusion Criteria:

- Are < 18 years of age

- Emergent or cardiovascular surgical procedure

- Are pregnant

- Participation in any other drug, device, or biologic study concomitantly, or within
the last 30 days (which may clinically interfere with this Clinical Study)

- Refusal of patient or authorized representative to sign consent