Evaluation of Anti-Xa Levels in Surgery Patients Receiving Weight-based Heparin
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology, Cardiology, Cardiology, Cardiology, Cardiology, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/6/2018 |
| Start Date: | March 23, 2018 |
| End Date: | October 1, 2019 |
| Contact: | Corinne Bertolaccini, PharmD |
| Email: | corinne.bertolacini@hsc.utah.edu |
| Phone: | 801-581-2167 |
The purpose of this study is to determine if weight-based heparin infusions at a rate of 10
units/kg/hour are sufficient to maintain a target anti-Xa of 0.1-0.35 IU/mL for VTE
prophylaxis in patients undergoing microvascular surgery. Additionally, a pilot protocol has
been developed to titrate these heparin infusions to ensure patients have sufficient VTE
prophylaxis. All patients will be enrolled in the observational arm of the study and receive
anti-Xa level monitoring. Patients with out-of-range anti-Xa levels will cross over to the
interventional arm of the study and receive real time heparin infusion dose adjustments per
the pilot protocol. The primary outcome measured will be the percentage of patients with
anti-Xa levels in the target range of 0.1-0.35 IU/mL while on a heparin infusion at 10
units/kg/hour.
units/kg/hour are sufficient to maintain a target anti-Xa of 0.1-0.35 IU/mL for VTE
prophylaxis in patients undergoing microvascular surgery. Additionally, a pilot protocol has
been developed to titrate these heparin infusions to ensure patients have sufficient VTE
prophylaxis. All patients will be enrolled in the observational arm of the study and receive
anti-Xa level monitoring. Patients with out-of-range anti-Xa levels will cross over to the
interventional arm of the study and receive real time heparin infusion dose adjustments per
the pilot protocol. The primary outcome measured will be the percentage of patients with
anti-Xa levels in the target range of 0.1-0.35 IU/mL while on a heparin infusion at 10
units/kg/hour.
Inclusion Criteria:
- Patients undergoing surgical procedures
- Initiation of a heparin infusion at a rate of 500 units/hour intraoperatively or
postoperatively
Exclusion Criteria:
- Age <18 years old
- Pregnant
- Incarcerated
- Mentally disabled
We found this trial at
1
site
201 Presidents Circle
Salt Lake City, Utah 84108
Salt Lake City, Utah 84108
801) 581-7200
Phone: 801-581-2167
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