A Pilot Study of Physical Activity for Improving Quality of Life in Prostate Cancer Patients on Androgen Deprivation Therapy (ADT)
| Status: | Completed |
|---|---|
| Conditions: | Prostate Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 40 - 80 |
| Updated: | 5/9/2018 |
| Start Date: | July 2008 |
| End Date: | June 2010 |
A Pilot Study of Physical Activity for Improving Quality of Life in Prostate Cancer Patients on Androgen Deprivation Therapy
60 eligible subjects will be randomized into one of three study arms 1) aerobic exercise, 2)
resistance exercise, or 3) usual care. Baseline measurements will be done on all study
subjects, these measurements include: height, weight, dual energy x-ray absorptiometry (DXA)
for bone mineral density and lean body mass measurements, blood will be taken to measure
serum free testosterone, prostate-specific antigen (PSA), glucose, and insulin levels.
Fitness will also be evaluated using a graded exercise test. Questionnaires on health and
personal history will also be completed. Men randomized to the aerobic exercise treatment arm
will participate in a walking program three times a week for eight weeks. The participants
will start at 15 minutes per session and increase to a goal of 60 minutes per session. Men
randomized to the resistance training treatment arm will participate in an eight-week program
of eight strength training exercises three times per week. Men in the usual care arm will
receive written materials from the American Cancer Society about coping with cancer, which
includes information about participation in physical activity. At the end of the eight week
intervention participants in all three study arms will complete the same questionnaires and
measurements they completed at baseline.
resistance exercise, or 3) usual care. Baseline measurements will be done on all study
subjects, these measurements include: height, weight, dual energy x-ray absorptiometry (DXA)
for bone mineral density and lean body mass measurements, blood will be taken to measure
serum free testosterone, prostate-specific antigen (PSA), glucose, and insulin levels.
Fitness will also be evaluated using a graded exercise test. Questionnaires on health and
personal history will also be completed. Men randomized to the aerobic exercise treatment arm
will participate in a walking program three times a week for eight weeks. The participants
will start at 15 minutes per session and increase to a goal of 60 minutes per session. Men
randomized to the resistance training treatment arm will participate in an eight-week program
of eight strength training exercises three times per week. Men in the usual care arm will
receive written materials from the American Cancer Society about coping with cancer, which
includes information about participation in physical activity. At the end of the eight week
intervention participants in all three study arms will complete the same questionnaires and
measurements they completed at baseline.
Inclusion Criteria:
- Men with metastatic prostate cancer receiving ADT and men who have failed primary
therapy and are receiving ADT.
- Men from the radiology practice who are receiving ADT as neoadjuvant therapy to
primary radiotherapy (enrolled only following completion of primary radiotherapy).
Exclusion Criteria:
- Men with the following counter-indications to exercise:
- Lower limb, bone, muscle, or joint pathology of a severity which limits their
ability to be physically active.
- A history of significant cardiac disease using criteria established by the
American College of Sports Medicine ( Criteria: pain, discomfort in the chest,
neck, jaw, arms, or other areas that may be due to ischemia; shortness of breath
at rest or with mild exertion; ankle edema; palpitations or tachycardia; known
heart murmur; unusual fatigue or shortness of breath with usual activities'
syncope)
- Other medical contraindications which would compromise participation in a
lifestyle physical activity program.
- Those who are currently physically active
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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