Behavioral Effects of Drugs: Inpatient (35)
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 7/12/2018 |
| Start Date: | June 1, 2018 |
| End Date: | May 2019 |
| Contact: | William W Stoops, PhD |
| Email: | william.stoops@uky.edu |
| Phone: | 8592575383 |
Influence of Methylphenidate and Duloxetine Maintenance on Pharmacodynamic Effects of Cocaine
This study will determine the influence of methylphenidate (Metadate®) and duloxetine
(Cymbalta®), alone and in combination, on the reinforcing, subjective and physiological
effects of cocaine.
(Cymbalta®), alone and in combination, on the reinforcing, subjective and physiological
effects of cocaine.
Inclusion Criteria:
- Recent cocaine use
Exclusion Criteria:
- Abnormal screening outcome (e.g., ECG, blood chemistry result) that study physicians
deem clinically significant
- Current or past histories of substance abuse or dependence that are deemed by the
study physicians to interfere with study completion
- History of serious physical disease, current physical disease, impaired cardiovascular
functioning, chronic obstructive pulmonary disease, history of seizure or current or
past histories of serious psychiatric disorder that in the opinion of the study
physician would interfere with study participation will be excluded from participation
- Females not currently using effective birth control
- Contraindications to cocaine, methylphenidate or duloxetine
We found this trial at
1
site
740 South Limestone Street
Lexington, Kentucky 40536
Lexington, Kentucky 40536
Principal Investigator: Craig R Rush, PhD
Phone: 859-257-5383
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