Effects of Exercise on Young Adult Women With ACEs: an Integrative Pilot Study
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 29 |
| Updated: | 8/19/2018 |
| Start Date: | May 1, 2018 |
| End Date: | March 31, 2019 |
| Contact: | Nathaniel D Jenkins, Ph.D. |
| Email: | nathaniel.jenkins@okstate.edu |
| Phone: | 4057449315 |
The process by which the body responds to stressors to maintain homeostasis is called
allostasis and is dependent on the integrated function of the nervous, endocrine, and immune
systems. ACEs adversely affect these system, cause allostatic load, and can modify
development of allostatic systems. However, the central hypothesis is that exercise can
reduce allostatic load by positively augmenting function of each of these three systems. No
previous studies have examined the effects of structured exercise interventions in
individuals with ACEs. The investigators are studying the effects of 8-weeks of structured
resistance and aerobic exercise on biomarkers related to nervous, endocrine, immune, and
metabolic function and several clinical outcomes in young adult women with ACEs. The specific
aims will test several hypotheses, and are as follows: SPECIFIC AIM 1: Conduct a feasibility
study to explore whether progressive, structured exercise can help mitigate the adverse
physiological effects of stress and trauma early in life. SPECIFIC AIM 2: Determine whether
progressive, structured exercise can help improve health-related quality of life, anxiety,
and traits like hope, self-efficacy, or self-control, resilience. SPECIFIC AIM 3: Determine
whether the type and timing of exposure to ACEs has a significant influence on the severity
of psychopathology and long-term physiological response to ACEs.
allostasis and is dependent on the integrated function of the nervous, endocrine, and immune
systems. ACEs adversely affect these system, cause allostatic load, and can modify
development of allostatic systems. However, the central hypothesis is that exercise can
reduce allostatic load by positively augmenting function of each of these three systems. No
previous studies have examined the effects of structured exercise interventions in
individuals with ACEs. The investigators are studying the effects of 8-weeks of structured
resistance and aerobic exercise on biomarkers related to nervous, endocrine, immune, and
metabolic function and several clinical outcomes in young adult women with ACEs. The specific
aims will test several hypotheses, and are as follows: SPECIFIC AIM 1: Conduct a feasibility
study to explore whether progressive, structured exercise can help mitigate the adverse
physiological effects of stress and trauma early in life. SPECIFIC AIM 2: Determine whether
progressive, structured exercise can help improve health-related quality of life, anxiety,
and traits like hope, self-efficacy, or self-control, resilience. SPECIFIC AIM 3: Determine
whether the type and timing of exposure to ACEs has a significant influence on the severity
of psychopathology and long-term physiological response to ACEs.
Inclusion Criteria:
1. provide written and dated informed consent to participate in the study;
2. be willing and able to comply with the protocol;
3. be between the ages of 18 and 29, inclusive;
4. be free from chronic cardiovascular, pulmonary, or musculoskeletal disease as
determined by a health history questionnaire;
5. not currently prescribed or taking anti-inflammatory or lipid-lowering medications;
6. have either an ACE score of 0 or 4 or higher;
7. have a BMI between 18.5 and 40.0, inclusive;
8. not enrolled in another clinical trial within thirty days prior to enrollment; and
9. answer no to all questions on the PAR-Q for people aged 15 to 69, which assesses a
person's eligibility to engage in exercise without contraindications.
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