Cannabis Observational Study on Mood, Inflammation, and Cognition
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 21 - 70 |
| Updated: | 8/9/2018 |
| Start Date: | July 1, 2016 |
| End Date: | April 30, 2021 |
| Contact: | Suzanne Taborsky-Barba |
| Email: | COSMIC.CUstudy@gmail.com |
| Phone: | 303-735-4486 |
Marijuana Harm Reduction: Innovative Strategies for Developing New Knowledge
This project examines the effects of cannabis on cognition and other domains of function and
whether those effects are dependent upon the ratio of THC to CBD in the product. Current
cannabis users are asked to stop using their typical product and to use cannabis containing
different ratios of the cannabinoids THC and CBD. Participants complete baseline assessments
including cognitive tasks, clinical measures, substance use history, and blood draw.
Participants then acquire and use their study strain on their own, and after a period of use
the mobile pharmacology laboratory goes to a location of their choosing. They complete
cognitive, motor and blood-based assessments, then leave the mobile lab to use their study
product one last time, returning to the mobile lab to complete cognitive, motor, and
blood-based assessments immediately after use and one hour after use. A small subset of
participants complete all of these procedures but use edible as opposed to flower-based
products.
whether those effects are dependent upon the ratio of THC to CBD in the product. Current
cannabis users are asked to stop using their typical product and to use cannabis containing
different ratios of the cannabinoids THC and CBD. Participants complete baseline assessments
including cognitive tasks, clinical measures, substance use history, and blood draw.
Participants then acquire and use their study strain on their own, and after a period of use
the mobile pharmacology laboratory goes to a location of their choosing. They complete
cognitive, motor and blood-based assessments, then leave the mobile lab to use their study
product one last time, returning to the mobile lab to complete cognitive, motor, and
blood-based assessments immediately after use and one hour after use. A small subset of
participants complete all of these procedures but use edible as opposed to flower-based
products.
Cannabis research can be dated back to the 1970's where standardized smoking of low potency
cannabis in a laboratory setting has been the primary method used to understand the effects
of the drug. The objective of this program is to use a naturalistic design to advance a more
nuanced understanding of the potential outcomes associated with using different strains of
marijuana. Researchers need to understand the effects of commonly used cannabis strains, as
they are used in every day life. Commonly available strains of cannabis sold in dispensaries
in Colorado have 3-5 times greater potency of cannabinoids, such as the psychoactive compound
tetrahydrocannabinol (THC), than what has been used in laboratory settings. It is possible
that laboratory based studies underestimate the effects of more potent strains that are
widely available. Also, scientists have focused on the effects of THC while mostly ignoring
other major cannabinoids (e.g. cannabidiol or CBD) and their synergistic relationship.
The objective of this study is to observe how different strains of marijuana, based off their
unique cannabinoid content, can influence your mental and physical state in real time. This
program will allow researchers to observe these effects immediately before and after cannabis
use. A participant will use cannabis in the comfort of their home, and will walk out their
front door and into a mobile lab that will be parked outside of their house. In this study,
there is no need to smoke and drive.
Participation is this study involves one appointment at the laboratory facility in Boulder
and one appointment in the mobile laboratory.
cannabis in a laboratory setting has been the primary method used to understand the effects
of the drug. The objective of this program is to use a naturalistic design to advance a more
nuanced understanding of the potential outcomes associated with using different strains of
marijuana. Researchers need to understand the effects of commonly used cannabis strains, as
they are used in every day life. Commonly available strains of cannabis sold in dispensaries
in Colorado have 3-5 times greater potency of cannabinoids, such as the psychoactive compound
tetrahydrocannabinol (THC), than what has been used in laboratory settings. It is possible
that laboratory based studies underestimate the effects of more potent strains that are
widely available. Also, scientists have focused on the effects of THC while mostly ignoring
other major cannabinoids (e.g. cannabidiol or CBD) and their synergistic relationship.
The objective of this study is to observe how different strains of marijuana, based off their
unique cannabinoid content, can influence your mental and physical state in real time. This
program will allow researchers to observe these effects immediately before and after cannabis
use. A participant will use cannabis in the comfort of their home, and will walk out their
front door and into a mobile lab that will be parked outside of their house. In this study,
there is no need to smoke and drive.
Participation is this study involves one appointment at the laboratory facility in Boulder
and one appointment in the mobile laboratory.
Inclusion Criteria:
- Have prior experience with edibles
- Have used marijuana in the past month. This includes any form of marijuana consumption
including flower, oil, wax, tinctures and edibles
- Not using other drugs (cocaine, opiates, methamphetamine) in the past 60 days
- Light alcohol use
Exclusion Criteria:
- Currently using a strain with greater than 1% CBD or less than 18% THC
- A University of Colorado student or employee
- Heavy tobacco use
- Are currently pregnant
- In treatment for psychotic disorder, bipolar disorder or schizophrenia
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