System for Determining Ideal Drug Doses for ADHD - Stages 1 and 2
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology, Psychiatric |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 8 - 12 |
| Updated: | 5/20/2018 |
| Start Date: | January 2016 |
| End Date: | June 2019 |
| Contact: | Abigail Z Rajala, PhD |
| Email: | arajala@wisc.edu |
| Phone: | 608-265-6711 |
Algorithm to Quantitatively Determine the Ideal Drug Dose to Treat Attention Deficit Hyperactivity Disorder
The goal of this study is to create a formal, quantitative methodology to determine what is
the most beneficial dose of Central Nervous System (CNS) stimulant (Ritalin, methylphenidate)
to improve cognitive and behavioral function of children diagnosed with Attention Deficit
Hyperactivity Disorder (ADHD) individually. If successful, it will change the way in which
the dose of CNS stimulant for treating ADHD is determined for children in need of therapeutic
intervention. The project will be focused on developing the necessary methodology to analyze
the children's data with the drift-decision model (DDM), and to develop the required
technology, i.e., a computer game with which to measure cognitive/behavioral function and its
validation with eye-tracking measurements.
the most beneficial dose of Central Nervous System (CNS) stimulant (Ritalin, methylphenidate)
to improve cognitive and behavioral function of children diagnosed with Attention Deficit
Hyperactivity Disorder (ADHD) individually. If successful, it will change the way in which
the dose of CNS stimulant for treating ADHD is determined for children in need of therapeutic
intervention. The project will be focused on developing the necessary methodology to analyze
the children's data with the drift-decision model (DDM), and to develop the required
technology, i.e., a computer game with which to measure cognitive/behavioral function and its
validation with eye-tracking measurements.
Inclusion Criteria:
- 8-12 years of age;
- Accompanied by caregiver (parent or legal guardian);
- Able to understand and speak English;
- Able to read basic English;
- No counseling or current/past history of psychiatric illness, as confirmed by the
Child Behavior Checklist (CBCL) and Conner's rating scale
Exclusion Criteria:
- a. Active psychosis or suicidality; b. History of primary psychotic disorder (e.g.,
schizophrenia) or bipolar disorder; c. Recent (past 2 weeks) substance abuse or
dependence; d. History of brain damage or significant developmental delay; e. Unstable
medical condition such as newly diagnosed Type I Diabetes or Rheumatoid arthritis; f.
Use of oral steroids; g. Participation in the last 30 days in a clinical study
involving an investigational drug; h. Current use of a psychotropic medicine
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