Sham CPAP vs. Straight CPAP for Chronic Cough
| Status: | Recruiting |
|---|---|
| Conditions: | Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 5/17/2018 |
| Start Date: | October 13, 2014 |
| End Date: | May 31, 2019 |
| Contact: | Krishna Sundar, MD |
| Email: | krishna.sundar@hsc.utah.edu |
| Phone: | 801-581-2016 |
Prospective Study of Efficacy of Sham CPAP vs. Straight CPAP on Cough Intensity in Patients With Chronic Cough
Chronic cough is an important clinical problem in primary care and sub-specialty practice.
Besides the distress experienced by patients with chronic cough, significant healthcare
resources are expended to understand the role of gastroesophageal reflux, asthma and
post-nasal drip in understanding their contribution to cough.
Obstructive sleep apnea (OSA) is common in patients with chronic cough. More importantly,
treatment of OSA with continuous positive airway pressure (CPAP) has led to improvement in
cough for chronic cough patients. Mechanisms by which OSA therapy with CPAP can improve cough
includes beneficial effects on reflux and airway inflammation.
The aim of this study is to definitively establish that CPAP therapy for treatment of OSA in
chronic cough patients improves cough. While these patients with chronic cough are not
routinely screened and treated for OSA, this study aims to evaluate these chronic cough
patients with screening questionnaires for OSA and if necessary with polysomnography and
randomize them to either CPAP or sham CPAP for 6 weeks.
Besides the distress experienced by patients with chronic cough, significant healthcare
resources are expended to understand the role of gastroesophageal reflux, asthma and
post-nasal drip in understanding their contribution to cough.
Obstructive sleep apnea (OSA) is common in patients with chronic cough. More importantly,
treatment of OSA with continuous positive airway pressure (CPAP) has led to improvement in
cough for chronic cough patients. Mechanisms by which OSA therapy with CPAP can improve cough
includes beneficial effects on reflux and airway inflammation.
The aim of this study is to definitively establish that CPAP therapy for treatment of OSA in
chronic cough patients improves cough. While these patients with chronic cough are not
routinely screened and treated for OSA, this study aims to evaluate these chronic cough
patients with screening questionnaires for OSA and if necessary with polysomnography and
randomize them to either CPAP or sham CPAP for 6 weeks.
Inclusion Criteria:
- Cough of more than 2 month duration
- Not active smoker with history of stoppage of smoking for more than 6 months
- Evaluation and treatment by other providers for suspected gastroesophageal reflux
disease (GERD), upper airway cough syndrome (UACS), or cough-variant asthma (CVA) for
at least 1 month
- Normal chest radiography or computed tomography (CT) scans (patients with up to 2 lung
nodules less than 3 mm will be allowed if there is no history of malignancy elsewhere)
- Normal spirometry with predicted diffusing capacity of the lung for carbon dioxide
(DLCO) more than 50% predicted. Pulmonary Function Test criteria: no evidence of
airflow limitation (FEV1/FVC > 0.7) or significant chest restriction (FVC > 70%
predicted) with predicted DLCO more than 50% predicted
Exclusion Criteria:
- Pregnancy
- Recent pneumonia (less than 6 months)
- Congestive heart failure, acute or chronic renal disease, jaundice or chronic liver
disease, pulmonary embolism, stroke or neurodegenerative disease, malignancy
- Use of supplemental oxygen or positive airway pressure therapy (if patients have been
diagnosed with obstructive sleep apnea in the past but were non-compliant with
positive airway pressure therapy, they will not be excluded)
- Use of opiates for cough suppression (opiate use for pain suppression can be included)
- Alcoholism, drug dependence (including chewing tobacco) or illicit drug use
- Esophageal cancer or laryngeal surgery
- Craniofacial abnormalities that preclude CPAP placement
We found this trial at
1
site
201 Presidents Circle
Salt Lake City, Utah 84108
Salt Lake City, Utah 84108
801) 581-7200
Phone: 801-581-2016
University of Utah Research is a major component in the life of the U benefiting...
Click here to add this to my saved trials
