Randomized, Placebo/Active Crossover Dose-ranging Study for Safety and Efficacy in Asthma Patients.

Inclusion Criteria:

1. Generally healthy, male and female adults aged 18 to 55 years at Screening.

2. Clinical diagnosis of intermittent, or mild-to-moderate persistent, asthma for at
least 6 months before Screening, and having used inhaled epinephrine or β-agonist(s)
for asthma control;

3. Demonstrating a baseline forced expiratory volume in 1 second (FEV1) at 50-90 percent
of predicted normal at Screening;

4. Demonstrating a 12.0 percent or greater airway reversibility in FEV1 within 30 min
after inhaling 2 actuations of Epinephrine CFC-MDI (440 mcg Epinephrine base) at
Screening;

5. Females of child-bearing potential must be non-pregnant, non-lactating, and practicing
a clinically acceptable form of birth control;

6. Demonstration of proficiency in the use of a MDI inhaler after training;

7. Having properly consented to participate in the trial.

Exclusion Criteria:

1. A smoking history of 10 or more pack-years, or having smoked within 6 months prior to
Screening;

2. Upper respiratory tract infections within 2 wk, or lower respiratory tract infection
within 4 wk, prior to Screening;

3. Asthma exacerbations that required emergency care or hospitalized treatment, within 4
wk prior to Screening;

4. Any current or recent respiratory conditions that, per investigator discretion, might
significantly affect pharmacodynamic response to the study drugs, including cystic
fibrosis, bronchiectasis, tuberculosis, emphysema, and other significant respiratory
diseases besides asthma;

5. Concurrent clinically significant cardiovascular, hematological, renal, neurologic,
hepatic, endocrine (including diabetes), psychiatric, neoplastic or other illnesses
that in the opinion of the investigator could impact on the conduct, safety and
evaluation of the study;

6. Known intolerance or hypersensitivity to any of the study MDI ingredients (i.e.,
Epinephrine, HFA-134a, CFC-12, CFC-114, polysorbate-80, ethanol, thymol, nitric acid
and ascorbic acid);

7. Use of prohibited drugs or failure to observe the drug washout restrictions;

8. Having been on other investigational drug/device studies in the last 30 days prior to
Screening.