Bioequivalence Study of Fixed Dose Versus Single Entities of Dolutegravir and Lamivudine

Inclusion Criteria:

- Between 18 and 55 years of age inclusive, at the time of signing the informed consent.

- Healthy as determined by the investigator or medically qualified designee based on a
medical evaluation including medical history, physical examination, laboratory tests
and cardiac evaluation (history, electrocardiogram [ECG]).

- A subject with a clinical abnormality or laboratory parameter(s) which is/are not
specifically listed in the inclusion or exclusion criteria, outside the reference
range for the population being studied may be included only if the investigator, in
consultation with the Medical Monitor if required, agree and document that the finding
is unlikely to introduce additional risk factors and will not interfere with the study
procedures.

- Subject must be able to swallow 2 tablets at the same time (Reference tablets only).

- Body weight >=50 kilogram (kg) for men and >=45 kg for women and body mass index (BMI)
within the range 18.5-31.0 kg per meter square (kg/m^2).

- Male or Female. Female subject: is eligible to participate if she is not pregnant (as
confirmed by a negative serum or urine human chorionic gonadotrophin [hCG] test), not
lactating, and at least one of the following conditions applies: 1. non-reproductive
potential defined as: pre-menopausal females with one of the following: documented
tubal ligation; documented hysteroscopic tubal occlusion procedure with follow-up
confirmation of bilateral tubal occlusion; hysterectomy; documented bilateral
Oophorectomy. Postmenopausal defined as 12 months of spontaneous amenorrhea; in
questionable cases a blood sample with simultaneous follicle stimulating hormone (FSH)
and estradiol levels consistent with menopause. Females on hormone replacement therapy
(HRT) and whose menopausal status is in doubt will be required to use one of the
highly effective contraception methods if they wish to continue their HRT during the
study. Otherwise, they must discontinue HRT to allow confirmation of post-menopausal
status prior to study enrolment. 2. Reproductive potential and agrees to follow one of
the options listed in the Modified List of Highly Effective Methods for Avoiding
Pregnancy in Females of Reproductive Potential (FRP) from 30 days prior to the first
dose of study medication and until at least five terminal half-lives OR until any
continuing pharmacologic effect has ended, whichever is longer after the last dose of
study medication and completion of the follow-up visit.

- Capable of giving signed informed consent which includes compliance with the
requirements and restrictions.

Exclusion Criteria:

- Alanine aminotransferase (ALT) and bilirubin >1.5x upper limit of normal (ULN)
(isolated bilirubin >1.5xULN is acceptable if bilirubin is fractionated and direct
bilirubin <35 percentage).

- Current or chronic history of liver disease, or known hepatic or biliary abnormalities
(with the exception of Gilbert's syndrome or asymptomatic gallstones).

- QT interval corrected for heart rate according to Fridericia's formula (QTcF) > 450
milliseconds (msec).

- Unable to refrain from the use of prescription or non-prescription drugs, including
vitamins, herbal and dietary supplements (including St John's Wort) within 7 days (or
14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is
longer) prior to the first dose of study medication, unless in the opinion of the
Investigator and ViiV Medical Monitor the medication will not interfere with the study
procedures or compromise subject safety.

- History of regular alcohol consumption within 6 months of the study defined as: An
average weekly intake of >14 drinks for males or >7 drinks for females. One drink is
equivalent to 12 gram (g) of alcohol: 12 ounces [360 milliliter (mL)] of beer, 5
ounces (150 mL) of wine or 1.5 ounces (45 mL) of 80 proof distilled spirits.

- Urinary cotinine levels indicative of smoking or history or regular use of tobacco- or
nicotine-containing products within 1 month prior to screening.

- History of sensitivity to any of the study medications, or components thereof or a
history of drug or other allergy that, in the opinion of the investigator or Medical
Monitor, contraindicates their participation.

- Creatinine clearance (CrCL) <90 mL/minute.

- A positive hepatitis B surface antigen (HBsAg) or a positive hepatitis B core antibody
with a negative hepatitis B surface antibody, positive hepatitis C antibody test
result at screening or within 3 months prior to first dose of study treatment.

- A positive pre-study drug/alcohol screen.

- A positive test for HIV antibody.

- Where participation in the study would result in donation of blood or blood product in
excess of 500 mL within 56 days.

- The subject has participated in a clinical trial and has received an investigational
product within the following time period prior to the first dosing day in the current
study: 30 days, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer).

- Exposure to more than four new chemical entities within 12 months prior to the first
dosing day.