Long-Term Study of EN3835 in Edematous Fibrosclerotic Panniculopathy (Cellulite)

Inclusion Criteria through Day 180:

- Voluntarily sign and date an informed consent agreement

- Have participated in and completed the double-blind Phase 3 study EN3835-302 or
EN3835-303

- Be willing to apply sunscreen to the buttocks before each exposure to the sun while
participating in the study during this period

- Be judged in good health

- Have a negative serum pregnancy test and be using an effective method of birth control

Inclusion Criteria beyond Day 180

- Received active EN3835 in the double-blind studies (EN3835-302/303) and not placebo

- Be willing to apply sunscreen to the buttocks before each exposure to sun while
participating in any re-treatment portion of the study.

- Have a negative urine pregnancy test and use an effective method of birth control, as
appropriate

Exclusion Criteria through Day 180:

- Intends to or has used other treatments for EFP on the buttocks at any time during the
study

- Intends to use tanning spray or tanning booths during the study

Exclusion Criteria beyond Day 180:

- Intends to or has used other treatments for EFP on the buttocks at any time during the
study

- Intends to use tanning spray or tanning booths during the study