Transcranial Magnetic Stimulation (TMS) for Primary Progressive Apraxia of Speech (PPAOS)

Apraxia of speech (AOS) is a motor speech disorder affecting the programming of motor speech
production. It is characterized by the impaired ability to coordinate the sequential,
articulatory movements necessary to produce speech sound. It can result from insult to the
brain, such as in stroke, or as the presenting sign/symptom of another neurodegenerative
disease.

TMS is a neurostimulation technique which has been shown to modulate cortical excitability in
a non-invasive manner, and has been associated with positive outcomes in a variety of
neurological and psychological disorders.There is evidence to support the role of TMS in
individuals with primary progressive aphasias. In addition, there is a a case report
suggesting an improvement in speech following TMS in an individual with primary progressive
AOS. This study is being undertaken to further examine the role of TMS in primary progressive
AOS.

Inclusion Criteria:

- Adults ages 18 and above who are able to consent

- Diagnosis of primary progressive apraxia of speech based on neurological evaluation

Exclusion Criteria:

- Any uncontrolled medical condition expected to limit life expectancy or interfere with
participation in the trial (i.e. unstable cancer, severe depression or anxiety by
DSM-IV criteria)

- Abnormal stress test, as determined by the treating physician (unless cardiology
clearance provided)

- Active substance abuse or alcohol dependence

- Uncorrected vision or hearing deficits that would preclude administration of the
cognitive measures

- Unwilling or unable to provide written informed consent

- History of fainting spells of unknown or undetermined etiology that might constitute
seizures

- History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or
family history of treatment resistant epilepsy

- No medication is an absolute exclusion from TMS. Medications will be reviewed by the
responsible MD and a decision about inclusion will be made based on the following:

- The subject's past medical history, drug dose, history of recent medication
changes or duration of treatment, and combination with other CNS active drugs.

- The published TMS guidelines review medications to be considered with TMS

- Any metal in the brain, skull or elsewhere unless approved by the responsible MD

- Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication
infusion pump, cochlear implant, vagal nerve stimulator) unless otherwise approved by
the responsible MD

- Substance abuse or dependence within the past six months

- Absence of corticospinal functional integrity