Abdominal Nerve Blockade in Chronic Heart Failure.
Status: | Recruiting |
---|---|
Conditions: | Cardiology |
Therapuetic Areas: | Cardiology / Vascular Diseases |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 3/1/2019 |
Start Date: | May 1, 2018 |
End Date: | May 1, 2020 |
Contact: | Manesh Patel |
Email: | manesh.patel@duke.edu |
Phone: | (919) 681-5816 |
Splanchnic Nerve Blockade in Chronic Heart Failure. Splanchnic CHF
Patients with chronic heart failure and undergoing right heart catheterization will be
enrolled in this study. Subjects will undergo catheterization of the heart to obtain central
cardiac pressure and other cardiac hemodynamic parameters. Subsequently, the subject will
undergo a regional nerve block of the splanchnic nerves.
This study will be a prospective, uncontrolled clinical trial. The study will not be
controlled as invasive monitoring of hemodynamics will be performed, allowing clear
demonstration of a cause-effect relationship. The goal of the study is to provide proof of
concept.
Patients will undergo detailed physiological testing.
enrolled in this study. Subjects will undergo catheterization of the heart to obtain central
cardiac pressure and other cardiac hemodynamic parameters. Subsequently, the subject will
undergo a regional nerve block of the splanchnic nerves.
This study will be a prospective, uncontrolled clinical trial. The study will not be
controlled as invasive monitoring of hemodynamics will be performed, allowing clear
demonstration of a cause-effect relationship. The goal of the study is to provide proof of
concept.
Patients will undergo detailed physiological testing.
Inclusion Criteria:
- Diagnosis of heart failure (HF)
- Symptomatic with dyspnea
- On a stable HF drug regimen
Exclusion Criteria:
- Ongoing treatment with oral anticoagulation other than aspirin
- Immunosuppressive medications for solid organ transplant
- Acute MI (STEMI or Type I NSTEMI) within 7 days
- Systolic blood pressure < 90 mmHg or >180 mmHg
- Infiltrative cardiomyopathy or constrictive cardiomyopathy
- Chronic kidney disease stage 5
- Pregnancy
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