Registry of Subjects With Drug Resistant Epilepsy and Treated With the VNS Therapy System.

The purpose of this registry is to evaluate clinical outcome and safety data in subjects with
drug resistant epilepsy treated with the VNS Therapy System. The study will collect outcomes
for subjects treated with VNS Therapy in a real-world setting.

Inclusion Criteria:

- Clinical diagnosis of drug resistant epilepsy treated with VNS Therapy. Eligible
subjects include those not previously treated with VNS Therapy as well as subjects
receiving replacement generators.

- Able and willing to comply with the frequency of study visits.

- Subject, or legal guardian, understands study procedures and voluntarily signs an
informed consent in accordance with institutional policies. In the event that the
subject is under the age of 18, the subject may also be required (per EC/IRB) to sign
an assent affirming their agreement to participate.

Exclusion Criteria:

• There are no exclusion criteria in this study. Investigators should refer to the local
instructions for use for VNS Therapy.