Mucosal Innate Immune Activation in Chronic Intestinal Disorders
| Status: | Recruiting |
|---|---|
| Conditions: | Irritable Bowel Syndrome (IBS), Irritable Bowel Syndrome (IBS), Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 99 |
| Updated: | 10/18/2018 |
| Start Date: | September 1, 2018 |
| End Date: | January 1, 2020 |
| Contact: | Julia Liu, MD |
| Email: | jjliu@uams.edu |
| Phone: | 5016865659 |
Crohn's disease and ulcerative colitis are types of chronic intestinal disorder called
inflammatory bowel diseases (IBD) that can affect the small and large bowel causing symptoms
of abdominal pain, diarrhea, blood in the stool, and weight loss. Irritable bowel syndrome
(IBS) is a milder form of IBD, with symptoms of abdominal pain, bloating, diarrhea or
constipation, and blood in the stool. It is not known what causes diseases such as IBD and
IBS. This study will look at the events in the gut that leads to leaky gut and inflammation
in patients with IBD and IBS. The study will also see if medications such as rifaximin and
mesalamine may reduce the amount of leaky gut.
inflammatory bowel diseases (IBD) that can affect the small and large bowel causing symptoms
of abdominal pain, diarrhea, blood in the stool, and weight loss. Irritable bowel syndrome
(IBS) is a milder form of IBD, with symptoms of abdominal pain, bloating, diarrhea or
constipation, and blood in the stool. It is not known what causes diseases such as IBD and
IBS. This study will look at the events in the gut that leads to leaky gut and inflammation
in patients with IBD and IBS. The study will also see if medications such as rifaximin and
mesalamine may reduce the amount of leaky gut.
Inclusion Criteria:
- Men and women, 18-years old and older
- Presenting at the University of Arkansas for Medical Sciences (UAMS) Endoscopy center
to undergo endoscopy with biopsy for surveillance, screening or diagnosis.
Exclusion Criteria:
- Subjects classified in an anesthesia risk group , American Society of
Anesthesiologists Class (ASA) ≥ 4,
- history of bleeding diathesis or coagulopathy
- stroke or transient neurological attack within the last 6 months
- pregnancy
- currently on blood thinners (excepting aspirin)
- subject is unable to consent themselves
We found this trial at
1
site
529 West Markham Street
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
(501) 686-7000
Phone: 501-686-5659
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
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