Effect of Ghrelin on Glucose Metabolism After Bariatric Surgery



Status:Active, not recruiting
Conditions:Obesity Weight Loss
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:21 - 65
Updated:5/23/2018
Start Date:September 2016
End Date:September 2019

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Trial Summary
Trial Overview
Inclusion Criteria
The purpose of this study is to determine if the altered nutrient exposure to the GI tract
after bariatric surgery reveals a negative incretin effect of ghrelin.


Inclusion Criteria:

- BMI ≥ 35 kg/m2

- Age 21-65 years

- Weight ≤ 200 kg

Exclusion Criteria:

- Type 2 or Type 1 diabetes

- Medications that alter insulin sensitivity or carbohydrate metabolism

- Positive pregnancy test

- Known history of intestinal diseases including, but not limited to, inflammatory bowel
disease (e.g. Chronic Ulcerative Colitis, Crohn's disease, celiac sprue)

- Prior gastric or intestinal surgery or pancreas resection

- History of cardiovascular disease, including but not limited to: myocardial
infarction, angioplasty, arrhythmia, uncontrolled hypertension

- History of chronic kidney disease or renal insufficiency; creatinine > 1.8 mg/dl.

- History of chronic liver disease, including but not limited to: cirrhosis, hepatitis,
portal hypertension; AST and/or ALT > 2x the upper limit of normal.

- Abnormal ECG
We found this trial at
1
site
Vanderbilt University Medical Center
1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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Nashville, TN
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