Evaluate the Efficacy and Safety of Fasinumab in Patients With Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hip or Knee

Key Inclusion Criteria:

1. Clinical diagnosis of non-radicular moderate-to-severe CLBP for ≥3 months (prior to
screening visit)

2. Clinical diagnosis of OA in at least 1 hip or knee joint based on the American College
of Rheumatology Criteria with radiographic evidence of OA (K-L ≥2) at screening

3. History of inadequate relief of CLBP from non-pharmacologic therapy

4. Willing to undergo joint replacement (JR) surgery, if necessary

5. History of regular analgesic medication use

6. History of inadequate pain relief or intolerance to analgesics used for chronic LBP

Key Exclusion Criteria:

1. Patient is not a candidate for MRI

2. History of major trauma or back surgery in the past 6 months prior to the screening
visit

3. History or presence of pyriformis syndrome

4. Evidence on baseline lumbar spine magnetic resonance imaging of potentially
confounding conditions

5. History or evidence on joint imaging of conditions that may confound joint safety
evaluation

6. Evidence or symptoms consistent with autonomic dysfunction (e.g., orthostatic
hypotension and/or autonomic symptoms) as defined in the protocol

7. Recent use of longer acting pain medications

8. Other medical conditions that may interfere with participation or accurate assessments
during the trial

Note: Other protocol defined Inclusion/ Exclusion criteria may apply.