Project UPLIFT for Psychogenic Non-Epileptic Seizures
| Status: | Recruiting |
|---|---|
| Conditions: | Depression, Neurology |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 2/23/2019 |
| Start Date: | July 23, 2018 |
| End Date: | July 31, 2019 |
| Contact: | Tara A. Ellis, BSN |
| Email: | tara.a.ellis@hitchcock.org |
| Phone: | 603-650-4646 |
The Feasibility of Project UPLIFT for the Treatment of Psychogenic Non-Epileptic Seizures
Developed by researchers from the Centers for Disease Control and Prevention (CDC), Project
UPLIFT (Using Practice and Learning to Increase Favorable Thoughts) is a group telephone
program designed to improve depression for people with epilepsy. Project UPLIFT uses
evidence-based approaches of cognitive-behavioral therapy (CBT) and mindfulness-based
cognitive therapy to help people manage and prevent symptoms of depression.
For people with psychogenic non-epileptic seizures, there are few treatment options for
depression that address the relationship between mood and seizures. There is evidence that
mindfulness-based therapy and cognitive therapy are both effective for people with
non-epileptic seizures, both in treating depression and reducing seizure frequency. In this
study, Project UPLIFT will be offered to patients with psychogenic non-epileptic seizures.
Project UPLIFT is facilitated by a trained clinician to groups of 4-8 patients over the
telephone. The group will meet at a regular time, once a week, for 8 consecutive weeks.
Participants will be assigned to one of two groups: an immediate-treatment or a waitlist
control group which will begin Project UPLIFT 3 months after enrolling in the study.
UPLIFT (Using Practice and Learning to Increase Favorable Thoughts) is a group telephone
program designed to improve depression for people with epilepsy. Project UPLIFT uses
evidence-based approaches of cognitive-behavioral therapy (CBT) and mindfulness-based
cognitive therapy to help people manage and prevent symptoms of depression.
For people with psychogenic non-epileptic seizures, there are few treatment options for
depression that address the relationship between mood and seizures. There is evidence that
mindfulness-based therapy and cognitive therapy are both effective for people with
non-epileptic seizures, both in treating depression and reducing seizure frequency. In this
study, Project UPLIFT will be offered to patients with psychogenic non-epileptic seizures.
Project UPLIFT is facilitated by a trained clinician to groups of 4-8 patients over the
telephone. The group will meet at a regular time, once a week, for 8 consecutive weeks.
Participants will be assigned to one of two groups: an immediate-treatment or a waitlist
control group which will begin Project UPLIFT 3 months after enrolling in the study.
Upon enrollment in the study, participants will be randomly assigned to one of two groups: an
immediate-treatment group, or a 3-month waitlist control group. Both groups will be given
surveys to complete online, and a seizure calendar to keep track of auras, seizures, and
events. The immediate-treatment group will be scheduled to start Project UPLIFT with their
trained facilitator. Each of the eight weekly sessions will take place at the same day of the
week and at the same time, and will last approximately one hour. Participants will have the
option of using a fake-name during the telephone calls to conceal their identity during the
group telephone calls.
After the 8 weekly sessions, both groups will be given a second set of online surveys to
complete individually. At this time, the waitlist control group will be scheduled to start
Project UPLIFT with the trained facilitator. After the waitlist group completes the final
session of Project UPLIFT, both groups will complete a third and final set of online surveys,
thus concluding all study procedures.
immediate-treatment group, or a 3-month waitlist control group. Both groups will be given
surveys to complete online, and a seizure calendar to keep track of auras, seizures, and
events. The immediate-treatment group will be scheduled to start Project UPLIFT with their
trained facilitator. Each of the eight weekly sessions will take place at the same day of the
week and at the same time, and will last approximately one hour. Participants will have the
option of using a fake-name during the telephone calls to conceal their identity during the
group telephone calls.
After the 8 weekly sessions, both groups will be given a second set of online surveys to
complete individually. At this time, the waitlist control group will be scheduled to start
Project UPLIFT with the trained facilitator. After the waitlist group completes the final
session of Project UPLIFT, both groups will complete a third and final set of online surveys,
thus concluding all study procedures.
Inclusion Criteria:
- History of psychogenic non-epileptic seizures, confirmed by study investigator.
- Literate
- Reliable telephone access
Exclusion Criteria:
- Dual diagnosis of PNES with epilepsy.
- Presence of serious mental illness that will impair ability to participate.
- Presence of active suicidal ideation at baseline with intention to act.
- Severe mental disability or estimated intelligent quotient (IQ) less than 70.
- No reliable telephone access.
We found this trial at
1
site
1 Medical Center Dr
Lebanon, New Hampshire 03756
Lebanon, New Hampshire 03756
(603) 650-5000
Principal Investigator: Lindsay M. Schommer, APRN
Phone: 603-650-4646
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