Comparison of 133Xe Scintigraphy With 19F MRI

Aim 1: Compare measures of lung ventilation performance obtained using 133Xe Scintigraphy
with performance using 19F Perfluorinated gas MRI using two independent readers.

133Xe Scintigraphy will be scored using the methods described in the statistics section and
19F images will be scored using the methods described in the statistics section. Scores for
each subject will be earluated for consistency between readers and modalities. 60%
concordance will be considered equivalent.

The outcomes of the work proposed is expected to show the non-inferiority of 19F
Perfluorinated gas MRI to 133Xenon Scintigraphy

Inclusion Criteria:

Subjects must meet all of the following inclusion criteria to be eligible for enrollment
into the trial

1. Outpatients of either gender, age > 18.

2. Willing and able to give informed consent and adhere to visit/protocol schedules.
(Consent must be given before any study procedures are performed.)

3. Women of childbearing potential must have a negative urine pregnancy test. This will
be confirmed before participation in this investigational protocol.

4. Completion of 133Xe ventilation scintigraphy after referral for ventilation imaging
for any reason in Pro00081987 A Comparison of Technegas® and Xenon 133 Planar Lung
Imaging in Subjects Referred for Ventilation Scintigraphy. The MRI will be
accomplished in a timely fashion after the Scintigraphy study based on scheduling
availability in the Center for Advanced Magnetic Resonance Development (CAMRD).

Exclusion Criteria:

Subjects presenting with any of the following will not be included in the trial:

1. Conditions that will prohibit MRI scanning (metal in eye, claustrophobia, inability to
lie supine)