Indocyanine Green Lymphangiography in Identifying Thoracic Duct During Neck Surgery

PRIMARY OBJECTIVES:

I. Feasibility and optimization of thoracic duct identification using indocyanine green (ICG)
lymphangiography.

II. To explore specifically how identifying the thoracic duct (TD) will prevent injury
intra-operatively.

III. To understand if a TD injury can be recognized by leakage of fluorescent chyle into the
operating field.

OUTLINE:

Participants receive indocyanine green solution subcutaneously (SC) and undergo near-infrared
imaging over 1-2 minutes during their standard of care neck surgery.

After completion of study treatment, participants are followed up for up to 1 year.

Inclusion Criteria:

- Healthy adult patients who are undergoing LEFT modified radical or selective
(including zone IV) lymph node dissection for any indication; this includes patients
who have had prior neck surgery

Exclusion Criteria:

- Children, minors, pregnant women, women who are breast feeding, institutionalized
patients

- Known prior allergic reaction to ICG or allergy to iodine

- Patients with excessively high anesthesia risks who cannot tolerate the extra time
under general anesthesia needed to perform this study; the surgeon and
anesthesiologist will determine this pre-operatively