Implementing Genomics in Practice (IGNITE): CYP2D6 Genotype-Guided Pain Management in Patients Undergoing Arthroplasty Surgery
| Status: | Recruiting |
|---|---|
| Conditions: | Post-Surgical Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 100 |
| Updated: | 3/17/2019 |
| Start Date: | June 7, 2018 |
| End Date: | May 2019 |
| Contact: | Ben Burkley |
| Email: | burkley@cop.ufl.edu |
| Phone: | 352-273-5283 |
This will be a randomized, open-labeled pilot pragmatic clinical trial. Patients undergoing
arthroplasty surgery will be recruited for CYP2D6 pharmacogenetic testing from UF Health
Gainesville and the Villages Orthopedic clinics to manage post-surgical pain. Patient will be
randomized to either usual care of genotype-guided care.
arthroplasty surgery will be recruited for CYP2D6 pharmacogenetic testing from UF Health
Gainesville and the Villages Orthopedic clinics to manage post-surgical pain. Patient will be
randomized to either usual care of genotype-guided care.
Inclusion Criteria:
- Scheduled to undergo total joint arthroplasty at area hospital
- Primary unilateral total hip or knee arthroplasty scheduled within approximately 6
months of the initial evaluation clinic visit
Exclusion Criteria:
- Patients scheduled to undergo a revision or bilateral procedure
- Receiving chronic opioid therapy, defined as use of opioids on most days for > 3 month
- Allergy to opioids will be excluded.
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