Insulin-Related Biomarkers and Exposures and Risk of Pancreatic, Lung, and Other Cancers
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 3 - 89 |
| Updated: | 6/20/2018 |
| Start Date: | June 22, 2018 |
| End Date: | March 19, 2020 |
Insulin-related Biomarkers and Exposures and Risk of Pancreatic, Lung and Other Cancers
Background:
Diabetes has been associated with many cancers including liver, pancreas, endometrial,
colorectal, breast and bladder cancer. Excess body fat has also been linked to cancer. One
reason for this might be resistance to insulin. Researchers want to look for links between
insulin, diabetes, and certain cancers. They want to study data that has already been
collected.
Objectives:
To study links between insulin, diabetes, and cancers. To study how the links might differ by
gender, race, and other factors.
Eligibility:
People who already participated in 1 of 8 cardiovascular disease studies
Design:
Researchers will study data that has already been collected. There will be no active
participants.
Participants gave permission to share their data. The data contain no personally identifying
information. Researchers will look at biomarkers like diet, medicines, and tobacco use. They
will do statistical analysis of the data
Diabetes has been associated with many cancers including liver, pancreas, endometrial,
colorectal, breast and bladder cancer. Excess body fat has also been linked to cancer. One
reason for this might be resistance to insulin. Researchers want to look for links between
insulin, diabetes, and certain cancers. They want to study data that has already been
collected.
Objectives:
To study links between insulin, diabetes, and cancers. To study how the links might differ by
gender, race, and other factors.
Eligibility:
People who already participated in 1 of 8 cardiovascular disease studies
Design:
Researchers will study data that has already been collected. There will be no active
participants.
Participants gave permission to share their data. The data contain no personally identifying
information. Researchers will look at biomarkers like diet, medicines, and tobacco use. They
will do statistical analysis of the data
There are multiple biological mechanisms that have been proposed for the association between
obesity and cancer including hormonal disruption (adipokines), inflammation, and growth
factor stimulation. A common unifying feature of all of these is insulin resistance, which is
strongly related to overweight and obesity. To extend the insulin and diabetes hypotheses, we
propose pooling data from eight well phenotyped cardiovascular disease cohorts
(Atherosclerosis Risk in Community-ARIC, Cardiovascular Health Study-CHS, Framingham study,
Multi-Ethnic Study of Atherosclerosis-MESA, Coronary Artery Risk Development in Young
Adults-CARDIA, Jackson Heart Study, and Honolulu Heart Program-HHP) to examine associations
for lung, pancreatic cancers, and possibly other cancers. These cohorts are ethnically
diverse and have fasting insulin and glucose measured at least 1 time during the study,
measured anthropometrics (including repeated measures of weight and BMI), lifestyle including
diet, tobacco, and alcohol use, and health history. Most of the studies have other clinically
measured biomarkers (e.g. CRP, HBA1c, hematology, and chemistry panel). We estimate that the
combined cohorts will total approximately 57,000 participants. Although none of the
individual cohorts have sufficient numbers of lung or pancreatic cancer cases alone, combined
they will facilitate an adequately powered study. This study uses anonomized data from
Biolinc.
obesity and cancer including hormonal disruption (adipokines), inflammation, and growth
factor stimulation. A common unifying feature of all of these is insulin resistance, which is
strongly related to overweight and obesity. To extend the insulin and diabetes hypotheses, we
propose pooling data from eight well phenotyped cardiovascular disease cohorts
(Atherosclerosis Risk in Community-ARIC, Cardiovascular Health Study-CHS, Framingham study,
Multi-Ethnic Study of Atherosclerosis-MESA, Coronary Artery Risk Development in Young
Adults-CARDIA, Jackson Heart Study, and Honolulu Heart Program-HHP) to examine associations
for lung, pancreatic cancers, and possibly other cancers. These cohorts are ethnically
diverse and have fasting insulin and glucose measured at least 1 time during the study,
measured anthropometrics (including repeated measures of weight and BMI), lifestyle including
diet, tobacco, and alcohol use, and health history. Most of the studies have other clinically
measured biomarkers (e.g. CRP, HBA1c, hematology, and chemistry panel). We estimate that the
combined cohorts will total approximately 57,000 participants. Although none of the
individual cohorts have sufficient numbers of lung or pancreatic cancer cases alone, combined
they will facilitate an adequately powered study. This study uses anonomized data from
Biolinc.
- All data included in this pooling project are being provided through an NHLBI
biorepository. The biorepository is called: BioLINCC.
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