Utilization of Oral Sucrose to Decrease Pain in Infants During Immunizations



Status:Completed
Conditions:Chronic Pain
Therapuetic Areas:Musculoskeletal
Healthy:No
Age Range:Any
Updated:5/27/2018
Start Date:November 1, 2003
End Date:October 11, 2006

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Efficacy of Oral Sucrose Analgesia During Routine Immunizations at 6 Weeks and 4 Months of Age

The study explores the potential benefits of a sugar water solution for decreasing pain in
infants during routine immunizations.

Acute pain during early life may alter infant pain responses, cognitive development, and
behavioral outcomes. Immunization injections represent a relatively brief exposure to acute
pain, yet assessment studies demonstrate that infants respond with significant distress
during the injections. This study will examine the analgesic potential of oral sucrose in
diminishing the pain associated with immunization injections in 6 week to 4-month-old
infants. The proposed mechanism of action is via the activation of endogenous opioids that
attenuate nociceptive information at the level of the dorsal horn.

Comparison: Administration of oral sucrose 2 minutes prior to immunizations compared to
administration of sterile water 2 minutes prior to immunizations

Inclusion Criteria:

- Currently between 2 and 4 months of age

- Birth between 37 and 42 weeks' completed gestation;

- Birth weight greater than 2.5 kg

- No evidence of acute or chronic disease processes.

Exclusion Criteria:

- They are experiencing concurrent illness

- They received an analgesic/sedative 6 hours prior to the office visit

- The infant has breast fed 30 minutes prior to the visit or wishes to breast feed
during or immediately after the immunization

- The infant has been introduced to solid food

- The infant may not receive a pacifier

- The infant is diagnosed with a major congenital disorder where the behavioral
responses to painful stimuli may be altered

- Language barriers preclude the process of obtaining parental consent.
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Hershey, PA
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