Preliminary Investigation of optimaL Oxygen Targets Trial
| Status: | Recruiting |
|---|---|
| Conditions: | Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/5/2018 |
| Start Date: | July 1, 2018 |
| End Date: | July 31, 2021 |
| Contact: | Matthew W Semler, MD |
| Email: | matthew.w.semler@vanderbilt.edu |
| Phone: | (615) 322-3412 |
Preliminary Investigation of optimaL Oxygen Targets (PILOT) Trial
Mechanical ventilation of ICU patients universally involves titration of the fraction of
inspired oxygen (FiO2) to maintain arterial oxygen saturation (SpO2). Despite decades of ICU
practice, however, the optimal SpO2 target remains unknown. Current guidelines offer
divergent recommendations as to the optimal SpO2 target. Therefore, we propose a
2,250-patient cluster-randomized cluster-crossover trial comparing a lower SpO2 target (90%;
range 88-92%), an intermediate SpO2 target (94%; range 92-96%), and a higher SpO2 target
(98%; range 96-100%) with regard to the outcome of days alive and free of invasive mechanical
ventilation.
inspired oxygen (FiO2) to maintain arterial oxygen saturation (SpO2). Despite decades of ICU
practice, however, the optimal SpO2 target remains unknown. Current guidelines offer
divergent recommendations as to the optimal SpO2 target. Therefore, we propose a
2,250-patient cluster-randomized cluster-crossover trial comparing a lower SpO2 target (90%;
range 88-92%), an intermediate SpO2 target (94%; range 92-96%), and a higher SpO2 target
(98%; range 96-100%) with regard to the outcome of days alive and free of invasive mechanical
ventilation.
Inclusion Criteria:
1. Age ≥ 18 years
2. Receiving mechanical ventilation through an endotracheal tube or tracheostomy
3. Admitted to the study ICU or admission to the study ICU from the emergency department
is planned
Exclusion Criteria:
1. Known pregnancy or beta hCG level greater than the laboratory upper limit of normal in
a patient capable of becoming pregnant
2. Known to be a prisoner
We found this trial at
1
site
1211 Medical Center Dr
Nashville, Tennessee 37232
Nashville, Tennessee 37232
(615) 322-5000
Phone: 615-322-3412
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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