Treatment Outcome in CBT for Cocaine Use

Study investigators will recruit treatment-seeking cocaine users (n = 100) from a separate
protocol (#6912) who will receive a standard 12-week course of cognitive behavioral therapy
for relapse prevention. Using a variety of self-report questionnaires and computer-based
tasks, three major domains will be assessed and evaluated as predictors of treatment outcome:
(1) impulsivity, (2) motivation to change, and (3) learning style. Measures of these factors
will have been obtained in the #6912 protocol. A better understanding of the impact of
impulsivity, motivation to change, and learning style on treatment outcome will provide
critical information to guide the refinement of CBT for cocaine abuse. For example, the
results of this study may help guide the development and introduction of more targeted
cognitive remedial strategies or behavioral training components into the framework of
evidenced-based practices. These additions may help ameliorate the deleterious effects of
specific participant characteristics on the acquisition and implementation of coping skills,
which can further improve the efficacy of CBT.

Inclusion Criteria:

1. Individuals age 18-60.

2. Currently report using cocaine via the intranasal or smoked route.

3. Be able to give informed consent and comply with study procedures.

Exclusion Criteria:

1. Individuals who meet current (i.e., within the past year) DSM-5 severe Substance Use
Disorder (SUD) criteria (defined as the presence of 6 or more symptoms) for drugs
other than cocaine, nicotine and caffeine.

2. Individuals who meet current (i.e., within the past year) DSM-5 moderate to severe
Major Depressive Disorder criteria (defined as a score of 17 or higher on the Hamilton
Depression Rating Scale).

3. Individuals who meet current DSM-5 criteria for any bipolar or psychotic disorder
(other than transient psychosis due to drug use), or for all other psychiatric
disorders not addressed by other exclusion criteria (e.g., anxiety disorders other
than specific phobias, eating disorders, or ADHD) that require medical and/or
psychological intervention.

4. Individuals with a neurodevelopmental disorder (e.g., Intellectual Development
Disorder, Autism Spectrum Disorder) except ADHD.

5. Individuals with uncorrected visual or auditory deficits, or who cannot adequately
read or understand the self-report assessment forms, or are so severely disabled they
cannot comply with the requirements of the study.

6. Individuals with current suicidal risk.

7. Individuals who are legally mandated (e.g., to avoid incarceration, monetary or other
penalties, etc.) to participate in substance abuse treatment program.

8. Individuals who are currently receiving any professional treatment (e.g., therapy,
medication) for substance abuse problems outside of the current research protocol.