A Study of RO7172508 in Patients With Locally Advanced and/or Metastatic CEA-Positive Solid Tumors

Inclusion Criteria:

- For Part I: participants with locally advanced and/or metastatic solid tumor with
confirmed cytoplasmic and/or membranous high CEA expression in tumor tissue is
required. Participants must have progressed on a SOC therapy, be intolerant to SOC,
and/or are non-amenable to SOC.

- For <12 mg dose cohorts, serum CEA levels below a certain threshold is required as
follows:

- For dose cohorts 65-159 microgram, a sCEA level of < 22 ng/mL

- For dose cohorts 160-399 microgram, a sCEA level of < 28 ng/mL

- For dose cohorts 400-799 microgram, a sCEA level of < 44 ng/mL

- For dose cohorts 800-1599 microgram, a sCEA level of < 70 ng/mL

- For the dose cohort of 1.6-3.1 milligram, a sCEA level of < 123 ng/mL

- For the dose cohort of 3.2-6.3 milligram, an sCEA level of < 229 ng/mL.

- For the dose cohort of 6.4-11.9 milligram, an sCEA level of < 440 ng/mL. If dose
fractionation is implemented, the sCEA threshold for inclusion should correspond
to the dose range of the first dose administered.

- For Part II, participants with locally advanced and/or metastatic solid tumor
expressing cytoplasmic and/or membranous high-CEA or moderate/low-CEA on archival
material, who have progressed on a SOC therapy, are intolerant to SOC, and/or are
non-amenable to SOC. Participants must have a lesion amenable to biopsy (except
participants with NSCLC, which may be enrolled with archival tissue available only).
For participants with colorectal cancer (CRC) only, the CEA assessment by
immunohistochemistry should be performed but the result is not required to enroll the
participant.

- Radiologically measurable disease according to RECIST v1.1.

- Life expectancy of >= 12 weeks

- Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0-1.

- All acute toxic effects of any prior radiotherapy, chemotherapy, or surgical procedure
must have resolved to Grade <= 1 or returned to baseline except alopecia (any grade)
and Grade 2 peripheral neuropathy.

- Adequate hematological, liver, renal, and lung function

- For women: agree to remain abstinent or use two contraceptive methods that result in a
failure rate of <1% per year from screening until 2 months after the last dose of
RO7172508 and have a negative pregnancy test within one week prior to the first study
treatment administration

- For men: remain abstinent or use contraceptive measures such as a condom plus an
additional contraceptive method that together result in a failure rate of <1% per
year, with partners who are woman of childbearing potential and refrain from donating
sperm during the study

Exclusion Criteria:

- History or clinical evidence of central nervous system (CNS) primary tumors or
metastases unless they have been previously treated, are asymptomatic, and have had no
requirement for steroids or enzyme-inducing anticonvulsants in the last 14 days before
screening.

- Non-irradiated lesions > 2 cm at critical sites where tumor swelling induced by
RO7172508 is expected to lead to significant complications.

- Another invasive malignancy in the last 2 years

- Evidence of significant, uncontrolled concomitant diseases that could affect
compliance with the protocol or interpretation of results or contraindicate the use of
an investigational drug.

- Uncontrolled hypertension, unstable angina, congestive heart failure, serious cardiac
arrhythmia that requires treatment with the exceptions of atrial fibrillation and
paroxysmal supraventricular tachycardia, and history of myocardial infarction within 6
months of enrollment.

- Active or uncontrolled infections.

- Known hepatitis B or C

- Major surgery or significant traumatic injury < 28 days prior to the first RO7172508
administration or anticipation of the need for major surgery during study treatment.

Specific Exclusion Criteria if Pre-treatment with Obinutuzumab is Implemented:

- Known HIV

- Positive test results for HBV infection, HBcAb indicating an active viral infection
and positive test results for HCV.

- Participants positive for HCV antibody are eligible only if polymerase chain reaction
(PCR) is negative for HCV ribonucleic acid (RNA).

- History of progressive multifocal leukoencephalopathy.

- Active TB requiring treatment within 3 years prior to baseline.

- Latent TB diagnosed during Screening.

- Positive test results for human T-lymphotropic virus 1