Resistance Training to Improve Fatigue and Physical Function in Postmenopausal Breast Cancer Survivors

Interventions that reduce pro-inflammatory cytokines with resultant stimulation of kynurenine
metabolism may be increasingly important in Breast Cancer Survivors (BCS) to prevent
susceptibility to cancer associated fatigue, depression, and declines in muscle mass and
function.

There is emerging evidence that supports exercise as a non-pharmacological therapy to prevent
cancer recurrence, sedentary behaviors, and obesity during cancer survivorship . It seems
that interventions that include resistance training (RT) are most efficacious at reducing
fatigue in BCS This study will begin to fill a knowledge gap by determine whether changes in
kynurenine metabolism occur following RT and relate to reductions in inflammation and
improved behavioral and physical function as this may identify potential targets for
interventions to promote cancer recovery.

Inclusion Criteria:

1. within 6 months to 10 years post active breast cancer therapy (i.e.
surgery/chemotherapy) for stage I-III invasive breast cancer,

2. at least 6 months post breast reconstruction (if applicable),

3. lack of menses for at least one year,

4. BMI 20-35 kg/m2,

5. fatigued (subjective reporting ≥3 on a 1-10 scale),

6. untrained with regard to structured resistance training (no more than 3x/week).

Exclusion Criteria:

1. plans for surgery (e.g., breast reconstruction) during the study period,

2. taking an anticoagulant medication (i.e. heparin, apixaban, rivaroxaban),

3. allergic to lidocaine,

4. orthopedic or chronic pain condition restricting exercise,

5. Mini-Mental Status Examination (MMSE) scores below education-specific cut-points (less
than 23 for more than 9th grade education and less than 17 for less than 8th grade
education),

6. unable to receive physician medical clearance.